Chicago Med Season 10 Cast: The Shocking New Doctors, Original Stars, And Who Just Left In 2025

The Gaffney Chicago Medical Center staff has undergone its most dramatic shake-up yet, with the premiere of Chicago Med Season 10 in late 2024 and continuing into the current 2025 broadcast schedule. The latest season introduces two major new series regulars, bringing fresh energy and conflict to the Emergency Department, while a handful of beloved original cast members remain the heart of the One Chicago medical drama. This in-depth guide provides the most current breakdown of the main cast, new additions, and the surprising reasons why fan-favorite doctors have recently closed their lockers for good.

The latest updates confirm that the show’s foundational pillars, S. Epatha Merkerson and Oliver Platt, are back, but they are joined by a new generation of doctors who are already shaking up the power dynamics. The shift in the Emergency Department leadership and the arrival of two high-profile actors signal a bold, new direction for the series, ensuring that the drama remains as intense as ever for long-time viewers and new fans alike.

The Current Main Cast of Chicago Med (Season 10, 2025)

The Chicago Med ensemble is a dynamic mix of veteran performers and rising stars. Below is a complete list of the main cast for the current season, along with a detailed biography of each actor and their character.

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• S. Epatha Merkerson as Sharon Goodwin: The steadfast Director of Patient and Medical Services has been a central figure since the pilot. Merkerson is a television legend, best known for her iconic 17-season run as Lieutenant Anita Van Buren on NBC’s Law & Order. Her character, Sharon Goodwin, is the moral compass of the hospital, often balancing the ethical dilemmas of the doctors with the cold realities of hospital administration.
• Oliver Platt as Dr. Daniel Charles: The Chief of Psychiatry is arguably the "soul" of the show, providing psychiatric evaluations and emotional support for patients and staff alike. Platt is a celebrated Canadian-American actor whose notable film roles include The Shining (1997) and more recently, a recurring role as Uncle Jimmy in the critically acclaimed series The Bear. He is one of only two remaining original cast members.
• Marlyne Barrett as Maggie Lockwood: The Charge Nurse of the Emergency Department, Maggie is the tough-but-caring backbone of the ED. Barrett, who previously appeared in shows like The Wire and films such as Hitch, has been an original cast member and a fan favorite, known for her powerful storylines involving her family and personal health struggles.
• Steven Weber as Dr. Dean Archer: Originally introduced as a recurring character, Dr. Archer was promoted to series regular, eventually becoming the Head of the Emergency Department. Weber is a veteran actor, famously known for his lead role as Brian Hackett on the long-running sitcom Wings. His character arc has been one of the most compelling, dealing with PTSD and a recent life-saving kidney transplant.
• Dominic Rains as Dr. Crockett Marcel: A talented and charismatic trauma surgeon, Dr. Marcel joined the cast in Season 5. Rains (born Amin Nazemzadeh) is an Iranian-American actor whose previous notable roles include Kasius in Marvel’s Agents of S.H.I.E.L.D. and Dr. Leo Julian on the soap opera General Hospital. His character is known for his surgical prowess and complex romantic relationships.
• Jessy Schram as Dr. Hannah Asher: Dr. Asher returned to the show as a series regular after a temporary departure, now working as an OB-GYN. Schram’s other prominent television roles include Karen Nadler in Falling Skies and Cinderella/Ashley Boyd in Once Upon a Time. Her character's journey has focused heavily on her recovery and commitment to a new, healthier life.
• Luke Mitchell as Dr. Mitch Ripley: Joining in Season 9, Dr. Ripley is an Emergency Medicine attending physician who has a complicated, troubled past with Dr. Dean Archer. Mitchell is an Australian actor known for his roles in Agents of S.H.I.E.L.D. and the soap opera Home and Away.
• Sarah Ramos as Dr. Caitlin Lenox: A major new series regular for Season 10. Dr. Lenox joins as the new Co-Head of the Emergency Department, immediately creating tension with the existing staff due to her strict, results-driven approach. Ramos is known for her roles in shows like Parenthood and American Dreams.
• Darren Barnet as Dr. John Frost: The second major new addition for Season 10, Dr. Frost is a new Emergency Medicine resident. Barnet is best known for his breakout role as Paxton Hall-Yoshida in the Netflix hit series Never Have I Ever. His character has a unique backstory, reportedly involving his time as a former child star, which is teased to create future dramatic storylines.

The Shocking Departures: Why Key Original Cast Members Left

The One Chicago franchise is famous for its revolving door of cast members, and Chicago Med is no exception. Season 8 and 9 saw the emotional exits of two of the show's most foundational characters, leaving only two original stars remaining.

The Exit of Dr. Will Halstead (Nick Gehlfuss)

Dr. Will Halstead, played by Nick Gehlfuss, was one of the series' main protagonists since the pilot, often involved in high-stakes ethical conflicts and dramatic romantic storylines, most notably with Dr. Natalie Manning. Gehlfuss departed the series in the Season 8 finale (2023).

The actor explained that his decision to leave was driven by creative reasons. He felt he had taken the character of Will Halstead as far as he could over eight seasons and was ready for a new professional challenge. His character’s emotional farewell saw him leave Chicago to reunite with his former love, Dr. Natalie Manning (Torrey DeVitto), providing a sense of closure for long-time fans of the couple.

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The Farewell to Dr. Ethan Choi (Brian Tee)

Another monumental loss was the departure of Dr. Ethan Choi, portrayed by Brian Tee. Dr. Choi was a fan-favorite, known for his military background and his journey from a reserved, rule-bound doctor to a more compassionate figure. Tee left the series after eight seasons in late 2022.

Tee’s exit was also a personal choice, as the actor sought to spend more time with his young family and pursue other creative opportunities, including directing. His character’s exit storyline was a happy one: Dr. Choi married his long-time love interest, April Sexton (Yaya DaCosta), and the couple decided to leave Gaffney to open a mobile clinic, giving the beloved character a well-deserved, peaceful send-off.

The Evolution of the Emergency Department and New Leadership

The dynamics of the Emergency Department (ED) have been completely redefined for the current season. The departure of Dr. Halstead and the promotion of Dr. Dean Archer left a vacuum in leadership, which is being filled by the new, no-nonsense Dr. Caitlin Lenox. Her immediate appointment as Co-Head of the ED signals a significant shift in the hospital’s operational style, moving away from the more personal, patient-first approach favored by the old guard.

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This new leadership structure, pairing the veteran Dr. Archer with the ambitious Dr. Lenox, is a primary source of conflict in Season 10. Dr. Lenox's strict adherence to rules and efficiency clashes directly with the more empathetic, sometimes rule-bending tendencies of other doctors, particularly Dr. Marcel and Dr. Asher. This focus on institutional authority versus personal ethics is a classic dramatic device that keeps the medical storylines fresh and engaging.

The introduction of Dr. John Frost, played by the recognizable Darren Barnet, adds another layer of intrigue. As a former child star, his character brings a unique celebrity baggage to the high-pressure environment of the ED, promising storylines that delve into the complexities of fame and personal identity in a medical setting. This casting choice is a clear indication that the producers are aiming for high-profile talent and more character-driven drama.

The Enduring Legacy of the Original Chicago Med Cast

While cast changes are inevitable in a long-running series, the longevity of S. Epatha Merkerson and Oliver Platt is a testament to their critical roles. They are the only two actors who have been main cast members since the series premiere in 2015, tying the show back to the larger One Chicago universe created by Dick Wolf. Their characters, Sharon Goodwin and Dr. Daniel Charles, provide the necessary stability and historical context for the hospital.

Their continued presence offers a crucial link to the series' roots, especially for viewers who remember other major original cast departures, such as Yaya DaCosta (April Sexton) and Torrey DeVitto (Dr. Natalie Manning) who both exited after Season 6. The core trio of Goodwin, Charles, and Maggie Lockwood (Marlyne Barrett) remains the emotional anchor, ensuring that despite the new faces and new conflicts, the heart of Chicago Med—the relentless fight for patient care—remains intact.

The combination of these enduring stars with the dynamic new talent of Sarah Ramos and Darren Barnet sets the stage for a compelling and high-stakes Season 10, proving that even after a decade on the air, the Gaffney Chicago Medical Center still has plenty of life-and-death drama left to explore.