The Definitive Guide To The 'St. Denis Medical' Cast: Where You've Seen The Mockumentary Stars Before

The cast of NBC's hit mockumentary-style medical comedy, *St. Denis Medical*, is a powerhouse ensemble of comedic veterans and rising stars, and with Season 2 currently airing new episodes in late 2025, fan interest is at an all-time high. This workplace comedy, from the creators of *Superstore* and *The Office*, follows the chaotic lives of the overworked and underfunded staff at an Oregon hospital, bringing a fresh, funny, and surprisingly poignant look at the healthcare industry. The series has successfully leveraged its talented core cast—led by Wendi McLendon-Covey and Allison Tolman—to become one of the most talked-about new sitcoms of the season. As of December 10, 2025, the show is deep into its second season, which premiered on November 3, 2025, continuing the stories of the dedicated (and often dysfunctional) doctors and nurses. From the no-nonsense hospital executive to the cynical emergency room doctor and the wide-eyed new nurse, the chemistry of the *St. Denis Medical* cast is the secret ingredient that has turned this show into a major hit for NBC and Peacock, drawing comparisons to classic mockumentaries with its unique blend of heart and dark humor.

Full Biography and Character Guide for the St. Denis Medical Cast

The success of any mockumentary series hinges on the believability and comedic timing of its ensemble. *St. Denis Medical* has assembled a stellar lineup, with each actor bringing a distinct comedic voice and a history of successful roles in both television and film. This list details the main cast members, their character roles, and their most notable previous work.

• Wendi McLendon-Covey as Joyce
  • Role: Joyce is the hospital's CEO, a no-nonsense executive who is constantly trying to keep the underfunded and chaotic facility operational while navigating the politics of healthcare.
  • Biography: An American actress and comedian, McLendon-Covey is a veteran of improv comedy. She is most famous for her ten-season run as Beverly Goldberg in the ABC sitcom *The Goldbergs*. Before that, she gained a cult following for her role as Deputy Clementine Johnson in the mockumentary series *Reno 911!*.
• Allison Tolman as Alex
  • Role: Alex is a Registered Nurse and the dedicated, conscience-driven head nurse who tries desperately to keep the team organized and on schedule, often failing due to the hospital's inherent chaos.
  • Biography: Tolman is an Emmy and Golden Globe-nominated actress known for her dramatic breakout role as Deputy Molly Solverson in the first season of the FX dark comedy-crime series *Fargo*. She also starred in the ABC series *Emergence*.
• David Alan Grier as Dr. Ron Leonard
  • Role: Dr. Ron Leonard is a witty, cynical, and veteran emergency room doctor who often provides a dry, observational commentary on the hospital's absurdities and the struggles of his colleagues.
  • Biography: A highly respected American actor and comedian, Grier is a Tony Award nominee and a founding cast member of the iconic sketch comedy series *In Living Color*. His extensive career spans Broadway, film, and television, including the satirical show *Chocolate News*.
• Josh Lawson as Dr. Bruce Schweitz
  • Role: Dr. Bruce is a talented but often arrogant surgeon who is highly self-aware of his own expertise. His comedic dynamic often comes from his self-assured, sometimes mean, interactions with the rest of the staff.
  • Biography: Lawson is an Australian actor, writer, and director. He is well-known for playing Doug Guggenheim in the Showtime series *House of Lies* and for his role as the video game character Kano in the 2021 film *Mortal Kombat*.
• Kahyun Kim as Serena
  • Role: Serena is a character who brings a mix of confidence and chaos, with her storyline expanding in Season 2 to include a fan-favorite romance arc.
  • Biography: Kim is a rising star who has quickly become a standout in the ensemble. Her role as Serena has been described as her "dream job," and she has spoken about how the writers have tailored the character's lines to fit her natural comedic style.
• Mekki Leeper as Matt
  • Role: Matt is a newly-hired Registered Nurse from Montana, often serving as the wide-eyed, relatable newcomer to the madness of St. Denis Medical.
  • Biography: Leeper is an Emmy Award-nominated comedian and actor who recently gained significant recognition for his role in the acclaimed mockumentary series *Jury Duty*.
• Kaliko Kauahi
  • Role: Kauahi's character is a key part of the supporting ensemble, though her specific role details are less publicized than the main six.
  • Biography: Kauahi is best known for her role as Sandra in the NBC sitcom *Superstore*, another successful workplace comedy from the same creative team (Justin Spitzer).

Why the 'St. Denis Medical' Cast is the New Face of Workplace Comedy

The casting choices for *St. Denis Medical* are not accidental; they are a deliberate strategy to capture the lightning-in-a-bottle success of past mockumentary hits like *The Office* and *Parks and Recreation*. The show's creators, Justin Spitzer and Eric Ledgin, have a proven track record of finding actors who excel in the subtle, camera-aware style of mockumentary performance. The ensemble's strength lies in its balance. You have the established mockumentary pedigree of Wendi McLendon-Covey from *Reno 911!*, the dramatic gravitas of Allison Tolman from *Fargo*, and the sketch comedy mastery of David Alan Grier from *In Living Color*. This mix allows the show to seamlessly shift between broad, slapstick comedy and moments of genuine, character-driven emotion, a hallmark of the best workplace comedies. Furthermore, the inclusion of fresh talent like Mekki Leeper (from *Jury Duty*) and Kahyun Kim ensures that the series feels current and introduces new, dynamic relationships. Leeper's character, Matt, provides a perfect audience surrogate, reacting to the bizarre environment of the underfunded hospital, while Kim's Serena adds a layer of unpredictable, confident chaos. This deliberate blend of familiar faces and new energy is what gives *St. Denis Medical* its unique topical authority in the crowded landscape of television comedy.

The Mockumentary Style: A Perfect Fit for the Medical Chaos

The choice to film *St. Denis Medical* in the mockumentary format is crucial to the cast's performance. This style, characterized by characters frequently breaking the fourth wall to address the camera, allows the actors to deliver razor-sharp one-liners and subtle facial expressions that convey more than dialogue ever could. It is the perfect vehicle to explore the stress and absurdity of the healthcare environment. The actors have embraced the improvisational nature that the format encourages. David Alan Grier, a master of improv, has noted how the unique comedy style of the show allows the cast to find a light-hearted side to the stress of the healthcare industry. Similarly, Wendi McLendon-Covey’s background in improv comedy is perfectly utilized as the hospital executive, Joyce, whose exasperated glances directly at the camera often punctuate the show's most ridiculous moments. This format also allows for deeper character development. Allison Tolman's character, Alex, the dedicated head nurse, uses her to-camera interviews to express the frustrations of her job and her attempts to maintain order, giving the audience intimate access to her conscience-driven motivations. The cast's ability to ground the comedy in genuine, relatable workplace struggles is what keeps the show from becoming a pure parody, instead positioning it as a smart, modern take on the medical drama genre.

St. Denis Medical: A New Era for Ensemble Comedy

With Season 2 now airing, *St. Denis Medical* has solidified its place as a must-watch NBC medical comedy. The show’s core appeal is the relatability of its setting—an underfunded hospital in Oregon—where the staff are trying their best despite the systemic challenges. The workplace comedy elements, such as the friction between the doctors and the nurses, the administrative chaos, and the personal lives of the staff, are all amplified by the cast's exceptional chemistry. The show is a testament to the enduring power of the ensemble cast. The comedic interplay between Dr. Ron and Dr. Bruce, the professional tension between Joyce and Alex, and the naive enthusiasm of Matt all contribute to a rich, layered narrative that keeps viewers coming back for more. This talented group of actors has not only made their characters memorable but has also successfully revived the mockumentary sitcom for a new generation, ensuring that *St. Denis Medical* remains a fixture in the comedy landscape for seasons to come.