The Full Star-Studded Cast Of Dr. Odyssey Episode 2: Who Are The Guest Stars In "Singles Week"?

The second episode of Ryan Murphy's high-stakes medical drama, Doctor Odyssey, titled "Singles Week," delivered a massive dose of star power and emotional chaos aboard The Odyssey luxury cruise ship, which aired on October 3, 2024. This highly anticipated installment not only deepened the romantic entanglements of the core medical team—Dr. Max, Nurse Avery, and Nurse Tristan—but also introduced a fresh wave of guest stars, including a country music legend and a beloved television heartthrob, guaranteeing a memorable voyage for viewers.

The show, which masterfully blends the procedural drama of a medical series with the opulent, often scandalous, backdrop of a luxury liner, uses its weekly theme—in this case, the chaotic search for love during "Singles Week"—to create unique, high-pressure medical and personal crises. Episode 2 was a pivotal moment, showcasing both the core cast's undeniable chemistry and the depth of the guest star lineup, which is a hallmark of a Ryan Murphy production. The stakes were raised with both a mysterious medical emergency and a dramatic rescue at sea.

The Complete Cast and Character Guide for Doctor Odyssey Episode 2: "Singles Week"

Episode 2, "Singles Week," brought back the established main cast and introduced a vibrant ensemble of guest actors whose characters were central to the episode's medical and romantic storylines. The following is a detailed breakdown of the actors and the roles they played in this pivotal episode.

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The Core Crew of The Odyssey

• Joshua Jackson as Dr. Max

  Biography: Born June 11, 1978, in Vancouver, Canada. Jackson is a veteran actor best known for his roles as Pacey Witter on Dawson's Creek, Peter Bishop on Fringe, and Cole Lockhart on The Affair. His character, Dr. Max, is the new, brilliant, and often boundary-pushing on-board doctor navigating the unique challenges of practicing medicine at sea while dealing with his own complex personal life.

• Phillipa Soo as Nurse Avery Morgan

  Biography: Born May 31, 1990, in Libertyville, Illinois. Soo is an acclaimed actress and singer, most famous for originating the role of Eliza Hamilton in the Broadway musical Hamilton, for which she received a Tony Award nomination. As Nurse Avery Morgan, she is the steadfast professional who balances the high-octane drama of the medical bay with her own romantic tensions.

• Don Johnson as Captain Robert Massey

  Biography: Born December 15, 1949, in Flat Creek, Missouri. Johnson is an iconic actor whose career spans decades, with signature roles including James "Sonny" Crockett in Miami Vice and the title role in Nash Bridges. Captain Massey is the charismatic and experienced leader of The Odyssey, whose personal life becomes a focal point of the episode due to a new romantic interest.

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• Sean Teale as Nurse Tristan Silva

  Biography: Born June 18, 1992, in London, England. Teale is known for his roles in the E4 show Skins, the CW series Reign, and the Fox series The Gifted. As Nurse Tristan Silva, he is a member of the small but mighty medical team, whose professional duties are complicated by his romantic rivalry with Dr. Max over Nurse Avery.

Notable Guest Stars of "Singles Week"

The theme of "Singles Week" allowed for an influx of high-profile guest stars, each playing a crucial role in the episode's intertwined storylines.

• Shania Twain as Heather

  Biography: Born Eilleen Regina Edwards on August 28, 1965, in Windsor, Ontario, Canada. Shania Twain is a global music icon, often referred to as the "Queen of Country Pop," with hits like "Man! I Feel Like a Woman!" and "That Don't Impress Me Much." In Doctor Odyssey, she plays Heather, a widow seeking a fresh start who immediately sparks a compelling connection with Captain Massey. Her character's storyline adds a layer of mature romance and intrigue to the episode.

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• Chord Overstreet as Sam

  Biography: Born February 17, 1989, in Nashville, Tennessee. Overstreet is an American actor and musician best known for his breakthrough role as Sam Evans on the hit Fox musical comedy-drama series Glee. In "Singles Week," he plays Sam, a young single guy who is enthusiastically "playing the field" during the themed cruise, bringing a lighthearted but central element to the romantic chaos.

• Kayla Compton

  Biography: Born February 3, 1990, in Salinas, California. Compton is an American actress, writer, and director who gained significant recognition for her recurring role as Allegra Garcia on The CW series The Flash. Her appearance in Episode 2 further diversifies the pool of passengers and potential patients aboard The Odyssey.

• Marcus Emanuel Mitchell

  Biography: Born on December 27th in Houston, Texas. Mitchell is an American actor known for his roles in television series such as Law & Order and as Dyonte in Good Trouble. His involvement in the "Singles Week" episode contributes to the dynamic environment of the cruise ship.

• Stephanie Suganami

  Biography: Also known as 'Steph Shep,' Suganami is an actor, entrepreneur, and environmental advocate. She is widely recognized for her background as the former assistant to Kim Kardashian. Her acting presence in this episode aligns with Ryan Murphy's penchant for casting figures with a strong public profile.

• Kassandra Cruz

  Biography: A model and actress of Venezuelan descent with a New Yorker upbringing, Cruz has a BFA in Dance. Her casting as a guest star adds to the diverse and energetic atmosphere of the cruise ship during the themed week.

"Singles Week": Plot Twists, Romantic Rivalry, and Medical Emergencies

The "Singles Week" theme was the engine driving the episode's dual storylines, creating a perfect storm of social and medical crises that put the medical team to the ultimate test.

The Love Triangle Heats Up

A central focus of Episode 2 was the escalating tension in the love triangle involving Dr. Max, Nurse Avery Morgan, and Nurse Tristan Silva. The episode finds Max and Tristan attempting to navigate the romantic indiscretions of the previous week's premiere. The "Singles Week" events, full of dancing and flirtation, only serve to heighten their competition for Avery's attention. The two men agree to an uneasy truce, setting the stage for more dramatic conflict in future episodes, proving that the personal lives of the crew are just as compelling as the medical cases.

A Medical Mystery and a Dramatic Rescue

Beyond the romantic chaos, the medical team faced two significant challenges. The first was a mysterious medical event that interrupts a romantic date, forcing Dr. Max to spring into action. This scenario is typical of Doctor Odyssey, where the everyday activities of the cruise are suddenly interrupted by life-threatening emergencies that require Max's unconventional and quick-thinking approach.

The second, and arguably most heartwarming, storyline involved a dramatic rescue at sea. While the ship was focused on finding love, the medical team was preoccupied with saving a woman who was found stranded. The episode culminates in a highly emotional reunion between this shipwrecked woman and her husband, who was also lost at sea. This subplot grounded the episode's action in genuine human drama and showcased the crew's dedication to saving lives, regardless of the setting.

Topical Authority and The Ryan Murphy Effect

The casting choices for "Singles Week" are a textbook example of producer Ryan Murphy's signature style. By securing high-profile names like Shania Twain and Chord Overstreet, Murphy ensures that Doctor Odyssey generates significant buzz and attracts diverse viewership.

Shania Twain's role as Heather is particularly noteworthy, as she is not just a one-off cameo but a recurring character who develops a meaningful relationship with Captain Massey. Her character's return in later episodes was confirmed, indicating that the romantic and personal storylines introduced during "Singles Week" have long-term consequences for the main cast. This strategy builds topical authority by weaving celebrity appearances into the fabric of the show's ongoing narrative, rather than using them as mere publicity stunts.

Furthermore, the inclusion of actors like Kayla Compton, known for her work in the Arrowverse, and Chord Overstreet, a fan favorite from Glee, taps into existing fan bases, driving traffic and conversation around the episode. The show effectively uses the high-stakes environment of the cruise ship, with its themed weeks and rotating passenger list, to justify this continuous stream of engaging guest stars and complex medical scenarios. The blend of established dramatic actors like Joshua Jackson and Don Johnson with unexpected celebrity cameos makes Doctor Odyssey a must-watch procedural drama.