Christina Applegate’s Brave Battle: 5 Heartbreaking Updates On Her MS Journey In December 2025

Christina Applegate, the beloved actress known for her sharp wit and iconic roles, continues to share her brutally honest and often heartbreaking journey with Multiple Sclerosis (MS), providing fans with the latest updates as of December 2025.

The star has been remarkably transparent about the physical and emotional toll the autoimmune disease has taken since her 2021 diagnosis, using her platform to shed light on the realities of living with a chronic condition, including recent struggles with mobility and a serious hospitalization this month.

Christina Applegate: A Complete Biography and Career Profile

Christina Applegate is an American actress whose career has spanned decades, moving seamlessly from iconic comedic roles to critically acclaimed dramatic performances. Her openness about her health struggles has made her an inspiration to millions battling chronic illness.

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• Full Name: Christina Applegate
• Born: November 25, 1971
• Birthplace: Los Angeles, California, U.S.
• Spouses: Johnathan Schaech (m. 2001; div. 2007), Martyn LeNoble (m. 2013)
• Children: Sadie Grace LeNoble (born 2011)
• Major Career Highlights:
  • Kelly Bundy in the Fox sitcom Married... with Children (1987–97).
  • Star of the sitcom Jesse (1998–2000).
  • Lead role in the film The Sweetest Thing (2002).
  • Lead role in the Netflix dark comedy series Dead to Me (2019–2022).
• Major Awards:
  • Emmy Award for Outstanding Guest Actress in a Comedy Series for her role in Friends.
  • Multiple nominations for a Golden Globe Award and Screen Actors Guild Award for Dead to Me.
• Health Battles:
  • Breast Cancer survivor (diagnosed in 2008).
  • Multiple Sclerosis (MS) diagnosis (2021).

The Latest MS Health Update: December 2025 Struggles

The end of 2025 has brought a wave of candid and challenging updates from Christina Applegate, highlighting a particularly difficult period in her life with Multiple Sclerosis. Her transparency serves as a powerful, unvarnished look at the disease.

Recent Hospitalization for Kidney Infection

In a concerning development, Christina Applegate was hospitalized in early December 2025 due to a severe kidney infection.

The actress described the experience as causing "so much pain," underscoring the compounding health issues that often accompany a chronic condition like MS.

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This hospitalization followed a "heartbreaking new health update" she shared just days earlier from a hospital bed, where she spoke about her ongoing battle.

The Emotional and Physical Toll of MS

Applegate has not shied away from describing the devastating impact MS has had on her daily life. She recently opened up on the "Conan O'Brien Needs a Friend" podcast, stating unequivocally that MS is the "worst thing" she has ever experienced.

This sentiment is particularly poignant coming from a breast cancer survivor, illustrating the profound, life-altering nature of the neurological disease.

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Candid Admissions on Mobility and Daily Life

The physical symptoms of Multiple Sclerosis have severely impacted Applegate’s mobility and independence, a topic she addresses with her characteristic blend of dark humor and raw honesty.

"My Legs Are Busted"

In a frank social media post, Applegate shared that her "legs are busted," a direct and powerful way to describe the severe fatigue, weakness, and pain she experiences.

Mobility issues are a central challenge for many with MS, making simple tasks incredibly difficult. The actress often uses a cane for public appearances, which she has referred to as her "walking stick."

The Struggle to Leave the House

Perhaps the most poignant recent revelation is her admission that she "doesn't leave the house anymore."

This statement, made during her interview with Conan O’Brien, highlights the isolating nature of chronic illness and the significant lifestyle changes she has had to embrace.

The difficulty of navigating the world with limited mobility and chronic pain has led to a more secluded life, focusing on her family—husband Martyn LeNoble and daughter Sadie Grace LeNoble—and her mental health.

Early Signs and The Journey to Diagnosis

Applegate's journey to her 2021 diagnosis was long and confusing, a common experience for those with autoimmune diseases.

Recalling Early MS Symptoms

She has recently shared a critical piece of her medical history, recalling that one of her earliest symptoms appeared years before her official diagnosis.

While shooting a pilot, she remembered running across a field and experiencing a strange, debilitating sensation.

Looking back, this moment of unexplained physical difficulty was likely an early manifestation of the neurological damage caused by Multiple Sclerosis, a disease where the immune system attacks the protective sheath of nerves.

Finding Support and Community

Despite the immense challenges, Applegate has found solace and strength in the MS community. She was diagnosed while filming the final season of her acclaimed show, Dead to Me, which required significant adaptations to the production schedule.

She has been "so supported by people that I know who also have this condition," a testament to the power of community in managing chronic illness.

Applegate’s willingness to discuss her journey—including interviews with Hoda Kotb and James Corden—is a beacon of hope and a powerful act of advocacy for MS awareness and research.