The All Saints’ Reunion: Where Is The Cast Of Nurse Jackie Now? (2025 Sequel Update)

The iconic, morally ambiguous world of All Saints’ Hospital is on the verge of a return, but the wait for the Nurse Jackie sequel has been a rollercoaster. Since the series finale in 2015, fans have been desperate to know if Jackie Peyton survived her shocking overdose and what became of her complex relationships with Zoey, Dr. O’Hara, and Eddie. As of late 2025, the biggest news is the development of a long-awaited sequel series, which has officially shifted hands from Showtime to Amazon MGM Studios, confirming that the story of the prescription drug-addicted nurse is far from over.

The original series, which ran from 2009 to 2015, captivated audiences with its dark humor and unflinching look at addiction, earning Edie Falco a Primetime Emmy Award for her unforgettable performance. With the show recently becoming a streaming hit on Netflix, a new generation of viewers is discovering the sharp-witted staff of the New York City emergency room. Here is the definitive, up-to-date look at the main cast of Nurse Jackie, their biographies, and the major projects they are working on in 2025, including the latest on the sequel’s status.

The Core Cast: Nurse Jackie Main Character Biographies and Profiles

The success of Nurse Jackie rested on its ensemble of deeply flawed and lovable characters. Here is a look at the most prominent entities from the All Saints’ Medical Center cast and their professional profiles.

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• Edie Falco (Jackie Peyton): Born July 5, 1963, in Brooklyn, New York. Falco is one of the most decorated actresses in television history, known for her groundbreaking roles as Carmela Soprano in The Sopranos and the titular character in Nurse Jackie. She is the only actress to have won the Emmy for Outstanding Lead Actress in both a Drama Series and a Comedy Series.
• Eve Best (Dr. Eleanor O'Hara): Born July 31, 1971, in London, England. A highly acclaimed English stage and screen actress, Best is a two-time Olivier Award winner and Tony Award nominee. Her role as Jackie’s best friend and confidante, Dr. O’Hara, was a fan favorite for its sharp wit and emotional depth.
• Merritt Wever (Zoey Barkow): Born January 1, 1980, in New York City. Wever is a critically acclaimed actress known for her quirky, Emmy-winning performances. Her portrayal of the enthusiastic but often naive student nurse, Zoey Barkow, provided much of the show’s heart and comic relief.
• Paul Schulze (Eddie Walzer): Born June 12, 1962, in New York City. Schulze is a veteran character actor, often playing complex or morally gray figures. His role as Eddie, the pharmacist and Jackie’s lover/pill supplier, was central to the series' addiction storyline.
• Peter Facinelli (Dr. Fitch "Coop" Cooper): Born November 26, 1973, in Queens, New York. Facinelli was already a recognizable star from the Twilight film franchise before playing the charming, narcissistic, and often clueless Dr. Cooper.
• Anna Deavere Smith (Gloria Akalitus): Born September 18, 1950, in Baltimore, Maryland. Smith is a celebrated actress, playwright, and professor, known for her documentary theater work. Her authoritative role as the hospital administrator, Akalitus, provided a perfect foil to Jackie’s rule-breaking.

The Shocking Status of the Nurse Jackie Sequel Series

The news that a sequel to Nurse Jackie is in development has been the subject of intense speculation among fans and industry insiders. The series finale, "I Say a Little Prayer," left Jackie’s fate ambiguous, collapsing on the emergency room floor after snorting a massive amount of heroin.

The sequel, which is set to pick up a decade after the original’s conclusion, would definitively answer the question: Did Jackie Peyton survive? Edie Falco is attached to reprise her Emmy-winning role, exploring themes of mental health issues and continued drug use, which she noted are still a significant danger in society.

However, the project has seen some turbulence. Originally announced for Showtime, the sequel series has since moved to Amazon MGM Studios, a major development that suggests the show is still very much alive but in a new creative home. Despite the progress, Falco herself offered a slightly disappointing update in a recent interview, indicating that while the project is "in the works," its development pace has been slow. Fans remain cautiously optimistic that the new decade-later story will finally arrive, bringing back the beloved, complicated nurse.

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Where Are the Nurse Jackie Cast Members Now in 2025?

Since the series wrapped in 2015, the ensemble cast of Nurse Jackie has gone on to star in some of the biggest and most critically acclaimed projects on television and film. The following are the most current updates on the All Saints’ Medical Center staff.

Edie Falco (Jackie Peyton)

Edie Falco has maintained her status as a television powerhouse. In 2025, she joined the cast of the Paramount+ hit series Mayor of Kingstown Season 4, starring opposite Jeremy Renner. Falco plays Nina Hobbs, a character that drastically shifts the power dynamics of the show, proving her enduring ability to command a complex, high-stakes role. Prior to this, she starred as the lead in the CBS series Tommy (2020).

Eve Best (Dr. Eleanor O'Hara)

Eve Best has achieved massive global recognition for her role as Princess Rhaenys Targaryen in the HBO fantasy prequel House of the Dragon. Her performance as the "Queen Who Never Was" has been a standout of the series, showcasing her dramatic range to a new audience. Her recent work also includes the BBC thriller Wild Cherry.

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Merritt Wever (Zoey Barkow)

Merritt Wever is perhaps the most critically active cast member, following up her Emmy-winning turn as Zoey with a string of acclaimed roles. Most notably, she starred in the Emmy-winning limited series Unbelievable and the genre-bending Apple TV+ hit Severance. Her distinct acting style continues to make her a sought-after talent in prestige television.

Peter Facinelli (Dr. Fitch "Coop" Cooper)

Peter Facinelli has transitioned into a multi-hyphenate career as an actor, producer, and filmmaker. In 2025, he is promoting his new film, Deadly Vows, and is also involved as a producer and actor in the upcoming film The Unbreakable Boy. He continues to engage with his massive fanbase from the Twilight saga, balancing commercial and independent projects.

Paul Schulze (Eddie Walzer)

Paul Schulze remains a prolific character actor across television and film. In recent years, he has appeared in streaming hits like Marvel’s The Punisher and Sneaky Pete. Schulze also has a unique side career as a DJ, even releasing a House DJ set in 2025, demonstrating his diverse creative interests outside of acting.

Anna Deavere Smith (Gloria Akalitus)

Anna Deavere Smith continues to focus on her influential work in theater and academia. In 2024–2025, she was the Artist in Residence at Wesleyan University and is developing a new play, The Basil Biggs Project, which draws inspiration from the United States’ 250th anniversary. Her focus remains on creating a new form of theater that blends performance and documentary.

Other Notable All Saints’ Personnel

• Stephen Wallem (Thor Lundgren): The actor who played the beloved gay nurse, Thor, remains active in the theater world. Wallem has performed his one-man musical revue, "Off the Wallem," and notably collaborated with Edie Falco on a cabaret show titled "The Other Steve and Edie."
• Dominic Fumusa (Kevin Peyton): Jackie’s long-suffering husband has appeared in various television roles, including the Amazon series The Purge and the crime drama Goliath.
• Ruby Jerins (Grace Peyton): Jackie’s daughter has continued her acting career with roles in films like Louder Than Bombs and has focused on her studies.
• Bobby Cannavale (Dr. Mike Cruz): The two-time Emmy winner who joined the cast in Season 5 has since starred in major HBO projects like Boardwalk Empire and Vinyl, and the popular series Nine Perfect Strangers.