5 Billionaire Quests For Immortality: Inside The Radical New Anti-Aging Technologies Of 2025

The quest to cheat death is no longer relegated to science fiction; it is the multi-billion dollar obsession of the world's wealthiest elite. As of December 2025, a small, yet powerful, cohort of tech titans is pouring vast sums into radical anti-aging technologies, turning themselves or their funded labs into living experiments. This intense, high-stakes pursuit of biological immortality has created a new frontier in science, driven by figures like Bryan Johnson, who is spending millions annually to reverse his biological age.

The term "rich guy who wants to live forever" has become synonymous with a new class of entrepreneur: the biohacker billionaire. These individuals are not just funding research; they are actively shaping the direction of longevity science, using their fortunes to accelerate technologies like cellular reprogramming, advanced diagnostics, and hyper-personalized health regimens that were unthinkable just a decade ago. Their efforts are generating the most current and cutting-edge data on human life extension.

The Ultimate Biohacker: Bryan Johnson's Profile and Project Blueprint

Bryan Johnson is the most visible and radical figure in the modern longevity movement, having dedicated his life and fortune to what he calls "Project Blueprint." His goal is to achieve the body of an 18-year-old.

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Bryan Johnson: Biography and Career Highlights

• Born: August 22, 1977, in Provo, Utah, USA.
• Education: Attended Brigham Young University (BYU) and earned an MBA from the University of Chicago Booth School of Business.
• First Major Company: Founded Braintree, an e-commerce payment processing company.
• Major Acquisition: Sold Braintree (which had acquired Venmo) to PayPal for a monumental $800 million in 2013.
• Post-Braintree Ventures: Founded OS Fund, a venture capital firm, and Kernel, a company focused on developing advanced neural interfaces and measuring brain activity.
• Current Focus: Project Blueprint, his extreme, data-driven anti-aging protocol.

Project Blueprint: The $2 Million-a-Year Protocol

Johnson's Blueprint is a meticulously documented, hyper-optimized regimen costing approximately $2 million per year. It is a 24/7 commitment to biological perfection, managed by a team of over 30 doctors and scientists who track dozens of biomarkers.

Key Components of Blueprint:

• Extreme Diet: A strictly vegan diet of exactly 1,977 calories, consumed early in the day.
• Supplement Stack: A daily cocktail of over 100 pills, including compounds like spermidine, senolytics, and NMN precursors.
• Rigorous Exercise: A one-hour, high-intensity workout routine, seven days a week.
• Advanced Monitoring: Daily measurements of his biological age (using epigenetic clocks), telomere length, organ performance (liver, kidney, heart), and continuous blood, stool, and urine analysis.
• Unique Procedures: Johnson has experimented with controversial methods, including receiving plasma transfusions from his teenage son, though he later paused this practice due to a lack of clear benefit.

As of late 2025, Johnson claims his efforts have resulted in having the heart of a 37-year-old, the skin of a 28-year-old, and the lung capacity of an 18-year-old, effectively reversing his biological age by over a decade. However, his methods remain highly controversial and are viewed by many as an economically unattainable form of medical extremism.

The Billionaire Backers: Funding the Future of Longevity Science

While Bryan Johnson is the most public-facing "rejuvenation athlete," the true financial firepower driving the science of immortality comes from other tech billionaires who prefer to invest in the research rather than become the primary experiment.

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1. Jeff Bezos and Altos Labs: Cellular Reprogramming

Amazon founder Jeff Bezos is one of the key investors behind Altos Labs, a biotech company that launched with an unprecedented $3 billion in funding. Altos Labs is focused on the cutting-edge field of cellular rejuvenation.

• Core Technology: The lab is centered on cellular reprogramming, a technique that uses specific molecular factors (Yamanaka factors) to revert adult cells to a younger, stem-cell-like state.
• Goal: To harness this process to reverse disease and damage, effectively creating a reset button for the body's tissues.
• Key Personnel: Altos Labs has recruited Nobel laureates and leading longevity scientists, demonstrating the seriousness of Bezos's investment in foundational, long-term biological research.

2. Peter Thiel and the Cryonics/Anti-Aging Drug Focus

PayPal co-founder Peter Thiel has consistently been one of the most outspoken proponents of life extension. His approach is multi-faceted, ranging from speculative technologies to established drug development.

• Cryonics Investment: Thiel has publicly supported the controversial practice of cryonics, the low-temperature preservation of bodies with the hope of future revival.
• Drug Development: He has poured tens of millions into startups researching anti-aging medicine and regenerative medicine, often focusing on compounds and therapies that target the molecular causes of aging.

3. Larry Ellison's Grants: Targeting the Root Cause

Oracle co-founder Larry Ellison views death as an unacceptable failure of technology. He has funneled hundreds of millions of dollars into anti-aging research through his foundation.

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• Focus: His grants are primarily aimed at understanding the fundamental mechanisms of aging, particularly research into telomere extension and the role of cellular senescence (the accumulation of "zombie cells").
• Impact: Ellison's significant financial contributions have been instrumental in legitimizing and accelerating academic research in this field.

The Cutting-Edge Technologies Driving the Immortality Dream

The combined investment of these billionaires is accelerating research across several key technological fronts, moving the conversation beyond simple diet and exercise into genetic and molecular manipulation.

1. Senolytics and Senomorphics

Senolytics are a class of drugs designed to selectively kill senescent cells—the "zombie cells" that stop dividing but refuse to die, instead releasing inflammatory signals that drive aging. Senomorphics aim to suppress the harmful secretions of these cells. This is a major area of focus for many funded biotech startups.

2. CRISPR and Gene Editing for Longevity

The gene-editing tool CRISPR is being explored as a method to correct age-related genetic mutations or to insert genes known to be associated with exceptional human longevity (centenarians). While still in early stages for human longevity applications, the potential for precise genetic control is enormous.

3. Hyperbaric Oxygen Therapy (HBOT) and Telomere Maintenance

Figures like Bryan Johnson regularly utilize Hyperbaric Oxygen Therapy (HBOT), which involves breathing pure oxygen in a pressurized chamber. Some studies suggest HBOT may help increase telomere length—the protective caps on chromosomes that shorten with age—though the long-term efficacy is still under rigorous study.

The Ethics and Economics of Eternal Life

The pursuit of immortality by the ultra-rich raises profound ethical and societal questions. The massive investment disparity—$2 million a year for one individual's protocol versus global health crises—highlights a growing longevity gap.

• Inequality: Critics argue that these technologies, if successful, will only be available to a tiny fraction of the population, creating a new class of "immortal elites" while the rest of humanity continues to age and die.
• Societal Strain: The prospect of radically extended lifespans challenges existing economic, social, and environmental models, from retirement systems to resource distribution.

Despite the controversies, the "rich guy who wants to live forever" narrative has provided an unprecedented catalyst for longevity research. Whether Project Blueprint or Altos Labs achieves true immortality remains to be seen, but their collective efforts are undeniably pushing the boundaries of human health and will likely lead to therapies that benefit the broader public in the form of extended "healthspan"—the number of years a person lives in good health.