The Untold Lives Of The Mangione Sisters: 5 Shocking Facts About MariaSanta And Luciana

The Mangione sisters, MariaSanta and Luciana, have been thrust into the national spotlight not for their own significant professional achievements but due to their familial connection to a high-profile criminal case. As of December 12, 2025, the public's curiosity about the siblings of Luigi Mangione—the man charged in the shocking murder of UnitedHealthcare CEO Brian Thompson—has driven intense scrutiny of their otherwise private lives. This article provides a deep dive into the established careers and biographies of the two sisters, revealing how they built impressive lives far removed from the controversy that now surrounds their family name.

The stark contrast between the sisters' successful, professional trajectories and their brother's alleged actions has become a central point of public discussion. From a distinguished career in cardiology to high-level corporate roles and visual arts, MariaSanta and Luciana Mangione represent a side of the family dedicated to academic and professional excellence. The following details their full biographies and the latest information on their current professional status.

Complete Biography and Professional Profiles

The Mangione family, originally based in Towson, Maryland, has a history rooted in business and professional achievement, with the sisters' parents, Louis and Kathleen Zannino Mangione, owning several franchises. The sisters, MariaSanta and Luciana, both pursued high-achieving paths, distinguishing themselves in their respective fields.

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• Full Name: MariaSanta Zannino Mangione
• Occupation: Physician-Scientist, Cardiologist
• Current Role: Clinical Fellow in Cardiology at the University of Texas Southwestern Medical Center (UTSW) in Dallas, Texas.
• Education: Vanderbilt School of Medicine, University of Maryland (Alumna).
• Hometown: Towson, Maryland.

• Full Name: Luciana Mangione (also referred to as Lucia Mangione Giulio)
• Occupation: Corporate Executive and Visual Artist
• Corporate Career: Division Vice President at Food Lion (2022-2023), Merchandising Director at Food Lion (2019-2022), Supply Chain professional.
• Artistic Passion: Described as a talented visual artist.
• Hometown: Baltimore, Maryland.

MariaSanta Mangione: A Physician-Scientist at UTSW

Dr. MariaSanta Mangione has dedicated her life to the demanding field of medicine, specifically cardiology. Her professional journey is marked by rigorous academic and clinical training, culminating in a prestigious fellowship at the University of Texas Southwestern Medical Center (UTSW).

Her work at UTSW as a Clinical Fellow in Cardiology places her at the forefront of cardiovascular medicine, combining patient care with research. She is recognized as a physician-scientist, indicating a commitment not only to treating patients but also to advancing medical knowledge through research and publication. This focus on cellular biology and clinical recognition highlights a career built on dedication and intellectual rigor.

The pursuit of a medical career requires years of sacrifice, beginning with her time at the University of Maryland and then her medical degree from the highly-regarded Vanderbilt School of Medicine. Dr. Mangione’s involvement in the health care sector is significant, and her name has appeared in reports detailing the Mangione family's extensive connections to hospital and assisted-living facilities.

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Luciana Mangione: From Corporate VP to Visual Artist

Luciana Mangione presents a fascinating professional profile, showcasing success across both the corporate world and the creative arts. While media reports often highlight her passion as a talented visual artist, her resume reveals a powerful trajectory in the retail and grocery industry.

Under the name Lucia Mangione, she held a senior executive role as a Division Vice President at Food Lion, a major American grocery chain. This role, which she held from 2022 to 2023, followed a promotion from her previous position as a Merchandising Director at the same company, a post she held for three years. Her corporate background also includes experience in supply chain management.

The dual nature of her career—a high-level corporate executive who is also a recognized artist—demonstrates a breadth of talent and ambition. Her corporate success in the competitive retail sector is a testament to her business acumen and leadership skills.

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The Family's Reaction and Public Entities

The sisters' connection to the Brian Thompson case has led to intense media scrutiny, prompting a rare public statement from the family. Louis and Kathleen Mangione, the parents, released a statement expressing profound shock and devastation following Luigi's arrest.

The statement emphasized the family’s distance from the alleged crime, noting that they were "devastated by Luigi's arrest" and that the events were completely unexpected. This public acknowledgment served to separate the professional and personal lives of MariaSanta and Luciana from the actions of their brother.

Other notable entities and family members frequently mentioned in connection with the Mangione sisters and their family include:

• Louis Mangione: Father, a businessman.
• Kathleen Zannino Mangione: Mother.
• Nino Mangione: Cousin, a state legislator, who also issued a statement in response to the allegations.
• UnitedHealthcare CEO Brian Thompson: The victim in the high-profile case.
• Vanderbilt School of Medicine: MariaSanta's alma mater.
• University of Texas Southwestern Medical Center (UTSW): MariaSanta's current professional institution.
• Food Lion: Luciana's former corporate employer.
• Towson, Maryland: The family's hometown.
• Baltimore, Maryland: Luciana's location.
• Gilman School: Luigi’s former school, where a teacher recalled his valedictorian speech.

Addressing Sensationalist Keywords

In the wake of the intense media coverage, numerous unverified and sensationalist rumors circulated online, including searches related to "OnlyFans" and other sensitive topics. It is important to note that these rumors were primarily linked to the brother, Luigi Mangione, and have been widely debunked or found to be satirical in nature. There is no credible or verifiable information connecting either MariaSanta Mangione or Luciana Mangione to any such accounts or activities. The focus of their public and professional lives remains squarely on their distinguished careers in medicine, business, and the arts.