The 15 Most Unforgettable Female Guest Stars Who Shook Up The Reagan Family On Blue Bloods (Including The Final Season's Surprises)

For over a decade, *Blue Bloods* has captivated audiences with the dramatic lives of the Reagan family, a multi-generational clan dedicated to New York City law enforcement. While the core cast—Tom Selleck, Donnie Wahlberg, Bridget Moynahan, and Will Estes—are the heart of the show, it is often the dynamic and powerful female guest stars who arrive to challenge, support, or complicate the Reagans' lives that create the most memorable episodes. As of December 12, 2025, with the final season (Season 14) wrapping up, the show has delivered a final wave of incredible talent, adding to a legacy of compelling performances. These actresses, many of them Emmy and Tony winners, have brought a necessary friction to Frank Reagan’s (Tom Selleck) office, Erin Reagan’s (Bridget Moynahan) courtroom, and Danny Reagan’s (Donnie Wahlberg) investigations. Their roles, ranging from high-powered politicians and police watchdogs to sympathetic witnesses and formidable adversaries, have significantly contributed to the show's topical authority and longevity.

The All-Star Lineup: Notable Female Guest Stars of Blue Bloods

The show’s long run, spanning 14 seasons, has seen an impressive roster of talented women grace the screen. These are the most unforgettable female guest stars who left a lasting impression on the Reagan family and the NYPD.

The Power Players: Actresses Who Challenged Frank Reagan

Frank Reagan, as the Police Commissioner, frequently butts heads with powerful figures who challenge his authority and ethics. Many of these formidable opponents have been played by celebrated actresses.

• Bebe Neuwirth (Inspector General Kelly Peterson): Perhaps the most significant recurring female guest star, Neuwirth appeared in multiple seasons (Seasons 4, 8, and 9) as the sharp-tongued Inspector General. Her role was to bring accountability and order to the NYPD, often putting her directly in conflict with Frank. Their tense, yet respectful, dynamic was a highlight for many years.
• Whoopi Goldberg (City Council Speaker Regina Thomas): The EGOT winner brought star power to the role of the powerful City Council Speaker. Her appearances were critical, typically involving high-stakes political disagreements with Commissioner Reagan, showcasing the complex relationship between the NYPD and city politics.
• Lorraine Bracco (Mayor’s Wife): Known for her iconic roles, Bracco made an appearance that added gravitas to the political landscape surrounding the Reagan family, proving that even minor roles could be filled by major talent.
• Tovah Feldshuh (District Attorney Rachelle T1): Feldshuh’s presence as a high-ranking legal adversary added depth to the procedural elements, particularly in scenes involving Erin Reagan.

The Fresh Faces of the Final Season (Season 14)

The show’s farewell season, Season 14, introduced new and exciting talent, ensuring the series went out with a bang by bringing in fresh dramatic entanglements for the Reagans.

• Mira Sorvino (Agent Kelly): The Oscar-winning actress joined the final season, making her first guest appearance in a highly anticipated role. Her involvement was a major draw for the final episodes, signaling a significant storyline.
• Debi Mazar (Jackie): Known for her roles in *Younger* and *Entourage*, Mazar also made a memorable debut in the final season. Her character, Jackie, brought a new energy and dramatic weight to the narrative.
• Amanda Kloots (Potential Girlfriend): *The Talk* host and former Broadway dancer appeared in Season 14, Episode 17, "Entitlement," in a role that was teased as a "potential girlfriend" for one of the Reagan men, sparking curiosity among fans about a possible late-series romance.
• Lori Loughlin (Season 14 Return): While not a new face, the return of Lori Loughlin’s character in Season 14, Episode 14, “New York Minute,” was a major talking point. Her reappearance as a returning guest star drove a significant plotline, demonstrating the show’s ability to weave in familiar faces for a final dramatic arc.

Early Career and Impactful One-Off Appearances

*Blue Bloods* has a history of featuring actors early in their careers or bringing in established stars for powerful single-episode storylines.

• Melissa Benoist (Season 1): Long before she became famous as *Supergirl*, Benoist appeared in the first season of *Blue Bloods*. Her early role is a fascinating look back at the show's history and her burgeoning career.
• Aunjanue Ellis: The Oscar-nominated actress appeared in a powerful guest role, showcasing the caliber of talent the show consistently attracts for its episodic stories.
• Christiani Pitts: A notable Broadway guest star, Pitts' appearance is part of a pattern where the show taps into New York's theater community for fresh talent.
• Andrea Roth (Season 1, Episode 1): She played a key role in the pilot episode, setting the tone for the type of intense, familial drama the series would become known for.
• Amy Carlson (Linda Reagan): While she was a main cast member, her sudden departure (death) at the beginning of Season 8 created one of the most significant dramatic shifts in the series, and her memory continues to influence Danny Reagan's storylines.

The Topical Authority: Why Female Guest Stars Matter to Blue Bloods

The revolving door of high-profile female guest stars is not just about star power; it is a crucial element of *Blue Bloods*' topical authority and success. The show thrives on depicting the complex moral and professional challenges faced by the Reagan family within the NYPD and the political landscape of New York City. The female guest stars often fill roles that directly challenge the patriarch, Frank Reagan, or his daughter, Erin Reagan, the Assistant District Attorney. For instance, the recurring role of Inspector General Kelly Peterson (Bebe Neuwirth) provided a consistent, institutional check on Frank’s power, grounding the show in a realistic depiction of police oversight. This tension between the police force and the oversight bodies is a central theme, and these actresses are essential to portraying that dynamic. Similarly, in Erin Reagan’s professional life, the guest stars often play key figures in the legal system—judges, opposing counsel, or powerful civic leaders like City Council Speaker Regina Thomas (Whoopi Goldberg). These roles allow the show to explore ethical dilemmas, the pursuit of justice, and the compromises inherent in the legal world, adding layers of complexity that keep the procedural elements fresh and engaging.

The Emotional and Personal Impact

Beyond the professional challenges, female guest stars have also been critical in the personal lives of the Reagan men. The introduction of Amanda Kloots in the final season as a potential romantic interest for one of the main characters highlights the show’s effort to address the personal voids left by past events, such as the loss of Linda Reagan. These personal storylines, though less frequent than the police work, are vital for connecting with the audience and exploring the Reagan family's emotional core. The show's ability to attract talent like Mira Sorvino and Debi Mazar for its final season demonstrates its continuing relevance and high standing within the television industry. Their roles often serve as major plot drivers, ensuring that the series maintains its high dramatic stakes right up to the very end.

A Legacy of Talent: 20+ Female Entities on Blue Bloods

To fully appreciate the depth of talent, here is a consolidated list of female entities, including the main cast, recurring, and notable guest stars, who have shaped the *Blue Bloods* universe:

1. Bridget Moynahan (Erin Reagan)
2. Amy Carlson (Linda Reagan)
3. Vanessa Ray (Eddie Janko-Reagan)
4. Abigail Hawk (Abigail Baker)
5. Bebe Neuwirth (Inspector General Kelly Peterson)
6. Whoopi Goldberg (City Council Speaker Regina Thomas)
7. Mira Sorvino (Agent Kelly)
8. Debi Mazar (Jackie)
9. Lori Loughlin (Returning Guest Star)
10. Amanda Kloots (Potential Girlfriend/Guest Star)
11. Tovah Feldshuh (DA Rachelle)
12. Lorraine Bracco (Mayor’s Wife)
13. Aunjanue Ellis (Guest Star)
14. Melissa Benoist (Season 1 Guest Star)
15. Christiani Pitts (Broadway Guest Star)
16. Andrea Roth (Pilot Episode Guest Star)
17. Swoosie Kurtz (Guest Star)
18. Mary Stuart Masterson (Guest Star)
19. Kathleen Munroe (Guest Star)
20. Mary B. McCann (Recurring as Judge)
21. Patricia Kalember (Recurring as Judge)
22. LaTanya Richardson Jackson (Guest Star)

The continuous incorporation of high-caliber female talent, both for long-running arcs and impactful single episodes, is a testament to the quality of *Blue Bloods*' writing and its commitment to exploring the full spectrum of New York's power structure. As the final season concludes, the legacy of these powerful women who stood toe-to-toe with the Reagans will remain a defining part of the show’s history.