The 15 Most Shocking & Powerful Female Guest Stars On Blue Bloods, Ranked (Final Season Updates!)

The final season of Blue Bloods, which premiered in late 2024 and concluded its historic run in 2025, brought with it a cavalcade of high-profile guest stars, ensuring the series went out with a bang. As of December 12, 2025, the buzz around the show's farewell episodes continues to highlight the incredible talent that has graced the screen, particularly the powerful female characters who have challenged, assisted, and sometimes even antagonized the Reagan family.

From Oscar-winning actresses to beloved daytime TV legends and controversial returning figures, the show's 14-season run has been a masterclass in utilizing guest talent to drive compelling, one-off storylines and build topical authority. This list delves into the most notable and impactful female guest stars, with a special focus on the fresh, final-season additions that captivated audiences.

The Final Season's Power Players: New and Returning Female Guest Stars

The conclusion of Blue Bloods saw the writers bring in several heavy hitters, positioning them in roles that directly intersected with the Reagans' professional lives. These appearances injected fresh energy and high stakes into the show's final chapters.

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1. Mira Sorvino as Fire Commissioner Veronica Radley

Oscar-winner Mira Sorvino joined the cast for a memorable turn in Season 14, Episode 13, "Bad to Worse," playing New York City Fire Commissioner Veronica Radley. Her character’s arrival created an immediate, high-tension dynamic with Frank Reagan, the Police Commissioner. This professional friction is a classic Blue Bloods trope, but Sorvino’s gravitas elevated the conflict, making Radley one of the most significant governmental guest roles of the final season.

2. Debi Mazar as Queens DA Evaline Romano

Known for her roles in *Younger* and *Entourage*, Debi Mazar stepped into the legal arena as Queens District Attorney Evaline Romano. Her character debuted in the final batch of episodes (Season 14, Episode 11, "Life Sentence"), immediately establishing a formidable presence opposite Erin Reagan. Mazar’s casting was a strategic move, introducing a new, powerful legal entity to challenge Erin's professional decisions as she navigated her own career path in the DA’s office.

3. Lori Loughlin as Grace Edwards (The Controversial Return)

One of the most talked-about guest appearances was the return of Lori Loughlin as Grace Edwards in Season 14, Episode 14, "New York Minute." Edwards is the widow of a police officer who was previously revealed to be a villainess in the Season 7 premiere, "The Greater Good." Loughlin’s reprisal of the role, seven years after her initial appearance, brought a layer of meta-commentary and a complex emotional storyline for Danny Reagan, making it a powerful and surprising entity for long-time viewers.

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4. Amanda Kloots as Deanne Janson

Television personality and former Broadway dancer Amanda Kloots made her primetime acting debut in Season 14, Episode 17, "Entitlement," playing a character named Deanne Janson. Kloots's appearance was notable for her public excitement about the role and the personal connection, as her late husband, Nick Cordero, had also appeared on the show. Her role was a fresh face in the series' penultimate episodes, adding a layer of contemporary celebrity appeal to the final run.

Notable Recurring and High-Profile Female Entities

Beyond the final season, Blue Bloods consistently featured celebrated actresses in roles that often required multiple appearances, adding depth and continuity to the Reagan family’s world.

5. Whoopi Goldberg as City Council Speaker Regina Thomas

Oscar-winner Whoopi Goldberg had a memorable recurring role as City Council Speaker Regina Thomas, a powerful political figure who frequently clashed with Frank Reagan. Her character was one of Frank’s most consistent political antagonists, appearing in two episodes, including the Season 8 episode "The Enemy of My Enemy." Goldberg's presence always guaranteed an intense, high-stakes debate at the Commissioner's office, exploring the difficult relationship between the NYPD and city politics.

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6. Bebe Neuwirth as Kelly Peterson

Broadway and television icon Bebe Neuwirth (*Frasier*, *Cheers*) was a significant recurring female character, appearing across multiple seasons. She played Kelly Peterson, the Inspector General for the NYPD. Her role was critical, often serving as an independent auditor and sometimes an adversary to Frank Reagan, creating complex ethical dilemmas at the highest levels of the police department.

7. Erika Slezak as Donna Duvall

Daytime television legend Erika Slezak (*One Life to Live*) appeared twice on the show as Donna Duvall, a neighbor of Henry Reagan. Her appearances were a nod to classic television and provided a warm, domestic contrast to the show's police procedural elements, often featuring in the quieter, character-driven moments with the Reagan patriarch.

The Extended Universe: Essential Female Recurring and Guest Roles

The strength of Blue Bloods lies in its deep bench of recurring characters and one-off guest stars who populate the world of the NYPD, the DA's office, and the Reagan dinner table. These female entities are crucial for building the show's long-term topical authority.

• Diane Neal as ADA Kelly Blake: Known for *Law & Order: SVU*, Neal played an Assistant District Attorney who worked opposite Erin Reagan, often adding a layer of professional rivalry and legal complexity.
• Jennifer Esposito as Detective Jackie Curatola: Though she was a main cast member for a time, Jackie Curatola’s departure and subsequent recurring status made her a notable female entity. She was Danny Reagan's original partner, and her abrupt exit was a major point of discussion for fans.
• Lauren Patten as Officer Rachel Witten: A recurring female officer who served as Eddie Janko’s partner for a time, providing a consistent presence in the patrol storylines.
• Sami Gayle as Nicky Reagan-Boyle: While a main character, Nicky’s shift to a recurring role after moving away for college meant she functioned as a significant, yet infrequent, guest entity, representing the younger Reagan generation's perspective.
• Carey Lowell as Janet Thompson: The actress, known for *Law & Order*, guest-starred as Janet Thompson in the episode "Tale of Two Cities," adding another familiar face to the legal landscape of New York.
• Geraldine Leer as Judge Barbara Carson: Appeared in the series finale, playing a minor but important role as a judge, showcasing the depth of the show's casting even in its final moments.
• Tamara Tunie as Monica Graham: Best known for *Law & Order: SVU*, Tunie appeared in the same Season 8 episode as Whoopi Goldberg, "The Enemy of My Enemy," as a guest star, further cementing the show's tendency to cast familiar faces from the New York procedural world.

The Enduring Legacy of Blue Bloods' Female Cast

While the focus is often on the guest stars, the backbone of the female presence on Blue Bloods has always been the main and recurring cast, whose characters served as the constant anchors for the guest stars to bounce off of. These entities include:

• Bridget Moynahan (Erin Reagan): The Assistant District Attorney, whose office was the primary intersection for legal guest stars like Debi Mazar and Diane Neal.
• Vanessa Ray (Officer Eddie Janko-Reagan): The patrol officer whose storylines often involved one-off guest stars playing victims, witnesses, or fellow officers.
• Abigail Hawk (Detective Abigail Baker): Frank Reagan's primary aide, whose presence in the Commissioner's office meant she interacted with nearly every high-level political guest star, including Whoopi Goldberg and Mira Sorvino.
• Marisa Ramirez (Detective Maria Baez): Danny Reagan's long-time partner, whose steady presence provided a constant female counterpoint to Danny's intense investigations, often dealing with the female guest stars at the heart of the crime.

The decision to bring in such diverse and high-caliber female talent for the final season—from Oscar-winner Mira Sorvino to the controversial return of Lori Loughlin—underscores the show's commitment to delivering compelling, fresh narratives until the very end. The legacy of Blue Bloods is not just in the Reagan family, but in the dozens of powerful women who passed through their lives, challenging their morals and shaping the narrative of New York justice.