The 20 Hottest Jobs Hiring In Philadelphia Right Now (December 2025)

The Philadelphia job market in late 2025 presents a complex yet opportunity-rich landscape, showing resilience in key sectors even as broader national trends indicate a cooling period. While the city's overall unemployment rate has edged higher, making the search for a new role competitive, the demand for specialized talent in Philadelphia's core industries—Life Sciences, Healthcare, and Technology—remains exceptionally strong.

For job seekers in December 2025, success hinges on targeting the specific sectors where growth is not just steady, but accelerating. The Education and Health Services supersector, in particular, has been a massive job creator, adding tens of thousands of positions over the last year. This comprehensive guide breaks down the 20 most in-demand roles, the employers actively hiring, and the salary expectations you should have in the City of Brotherly Love.

Philadelphia's Top 4 High-Growth Sectors and Salary Expectations (2025)

Philadelphia’s economic engine is powered by a diverse mix of world-class universities, major financial institutions, and a burgeoning tech scene. The key to landing a high-paying job in the current market is understanding where the most significant investment and hiring is taking place.

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1. Life Sciences and Biotech: The Cell and Gene Therapy Hub

Philadelphia is a global leader in cell and gene therapy, driving massive demand for highly specialized roles. The New Jersey/Philadelphia corridor offers some of the strongest salaries in the industry, making it a prime target for experienced professionals.

• In-Demand Roles: Clinical Research Associate, Laboratory Technician, Regulatory Affairs Specialist, Bio-manufacturing Engineer.
• Salary Snapshot: While the average Life Sciences salary is around $47,575 per year, specialized mid-level roles, such as a Life Sciences Corporate Associate, can command upwards of $225,000+.
• Key Employers: Trustees of the University of PA (a top employer overall), various biotech startups, and major pharmaceutical companies.

2. Healthcare and Education: Unstoppable Growth

The Education and Health Services supersector is the undisputed leader in job creation for the Philadelphia metro area. The region ranks fourth among metropolitan areas for the highest employment levels in healthcare practitioners and technical occupations. The School District of Philadelphia, for example, is consistently hiring.

• In-Demand Roles: Registered Nurse (RN), Certified Nursing Assistant (CNA), Nurse Practitioner, Special Education Teacher, Grants Accountant, Physician Assistant.
• Salary Snapshot: The average hourly rate for general healthcare is about $19.20. However, advanced roles are highly lucrative: a Nurse Practitioner averages around $129,210 per year, and top positions like OB-GYN can exceed $281,390.
• Key Employers: The School District of Philadelphia, Trustees of the University of PA, and the Federal Government (which employs many healthcare workers).

3. Technology and Financial Services: High-Value Roles

Philadelphia is ranked as the 18th largest U.S. tech market, boasting a strong startup environment and major corporate presence. The average salary for a tech worker in the city is a significant draw, often exceeding $121,000 annually.

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• In-Demand Roles: Data Scientist, Software Engineer, Cybersecurity Analyst, Audit Manager (in Financial Services).
• Salary Snapshot: The average IT salary is approximately $104,850 per year, with some reports showing the average base salary for all tech workers at $130,192.
• Key Employers: Microsoft (a "Best Place to Work" in 2025), PwC (offering remote programs), and various financial institutions.

4. Public Service and Infrastructure: Essential Openings

Government and infrastructure roles offer stability and excellent benefits. The city is actively recruiting for essential services.

• In-Demand Roles: Police Officer Recruit, Welder, Infrastructure Technician.
• Salary Snapshot: Police Officer Recruits start at a competitive $66,931.
• Key Employers: Philadelphia Police Department, Federal Government, and Amtrak (for infrastructure and corporate roles).

Targeting Your Search: Entry-Level, Remote, and Part-Time Opportunities

The Philadelphia job market offers flexibility for job seekers at every stage of their career, from recent graduates to those seeking flexible work-from-home options. Leveraging the right keywords and platforms is crucial for these specialized searches.

Top Entry-Level Jobs Philadelphia (2025 Graduates)

Recent graduates and those new to the workforce will find numerous opportunities, particularly in the financial and administrative sectors. Companies are hiring for roles that offer on-the-job training and a career pathway.

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• Trade Lifecycle Analyst: A common starting point in the Financial Services sector, focusing on transaction processing and risk.
• Associate Personal Banker: Roles often available in the Metro Philadelphia District, requiring strong customer service skills.
• Supply System Analyst / IT Specialist: Government and defense contractors frequently hire entry-level analysts for IT and logistics support roles.
• Casino Social Media Associate (Remote Available): A growing number of remote-friendly, entry-level marketing roles are emerging in the entertainment and tech industries.

Best Remote Jobs Philadelphia (Work From Home LSI)

The shift to hybrid and fully remote work continues to benefit Philadelphia residents, with major national and local companies maintaining robust work-from-home programs.

• Audit Manager (Tech Industry): High-level financial oversight roles are frequently offered remotely by major firms.
• Manager, Outsourced Accounting: Specialized accounting roles, especially those serving specific client niches like Skilled Nursing Clients, are often virtual.
• Customer Service Representative (Contractor Role): Large-scale operations like Omni Interactions are continually hiring remote customer service reps, offering a flexible work-from-home option.
• Companies with Remote Programs: PwC and other consulting firms are known for offering remote flexibility to Philadelphia-based employees.

In-Demand Part-Time Jobs Philadelphia (Flexible Schedules)

For those seeking supplementary income or flexible hours, the part-time market is strong, with an emphasis on administrative and data-focused roles.

• Part-Time Data Entry Clerk: Highly flexible and often remote, with a significant number of openings available through platforms like Earn Haus.
• Retail and Hospitality: While not always high-paying, the city's vibrant retail and restaurant scene always has openings, especially in Center City.
• Work From Home / Remote Customer Service: Many part-time roles are available in customer service and administrative support, offering pay in the $14-$33 per hour range.

The Ultimate Job Search Toolkit: Platforms and Strategies

To maximize your chances of securing a position in Philadelphia's competitive market, you must go beyond the general job boards and tap into niche, local resources.

Essential Job Search Platforms

While the major aggregators are crucial, Philadelphia job seekers should also target platforms that focus specifically on the local ecosystem.

1. General Aggregators: Indeed, LinkedIn, Glassdoor, Monster, and ZipRecruiter remain the standard starting points for all job types.
2. Tech & Startup Niche: Built in Philadelphia is the go-to resource for finding tech jobs, startup roles, and the best tech companies to work for in the city.
3. Local Workforce Development: Philadelphia Works and The Pennsylvania Key offer excellent resources, including High Priority Occupation (HPO) lists and job training programs aligned with employer demand.
4. Government & Public Service: Check the official websites for the City of Philadelphia, the Philadelphia Police Department, and the School District of Philadelphia for direct application portals.

Networking and Career Strategy (Topical Authority)

In a cooling market, networking and targeted applications become more important than ever. Focus on the employers who are consistently ranked as top workplaces.

• Target Top Workplaces: Companies like Microsoft, Schneider Electric, and Booz Allen Hamilton were recognized as top workplaces in 2025. Targeting their career pages directly can bypass high-volume job board competition.
• Leverage University Connections: Given the dominance of the University of Pennsylvania and other academic institutions, utilize alumni networks and career services, as these schools are major employers in the region.
• Focus on Skills Gaps: The demand for specialized skills in Life Sciences, Data Science, and Cybersecurity is high. Investing in a quick certification in Agentic AI or other emerging technologies can make your resume stand out instantly.

The Philadelphia job market in late 2025 is clearly bifurcated: challenging in general but booming for specialized roles. By focusing your search on the high-growth sectors—Healthcare, Life Sciences, and Technology—and utilizing the specific local job platforms, you can navigate the market effectively and secure one of the city's many high-value career opportunities.