The $2 Million Man: Bryan Johnson's 2025 Blueprint Protocol And His War On Death

Bryan Johnson, the American tech entrepreneur and venture capitalist, remains one of the most polarizing figures in the world of longevity, spending an estimated $2 million per year on his radical anti-aging regimen, Project Blueprint. As of December 2025, Johnson's quest to achieve the body of an 18-year-old has entered a new, highly-publicized phase, marked by a major Netflix documentary and the release of his book, 'Don't Die,' solidifying his position as the world's most measured human.

The core of Johnson’s mission is to defeat death itself and establish "health as a service," using technology and extreme self-quantification to optimize every single organ in his body. His regimen, which is managed by a team of over 30 doctors, involves precise control over his diet, exercise, and a complex stack of pharmaceuticals and supplements that he continually adjusts based on the latest scientific data and his own measured results.

Bryan Johnson: A Complete Biography and Financial Empire

Bryan Johnson is not merely a biohacker; he is a highly successful entrepreneur whose financial freedom provided the foundation for Project Blueprint. Born on August 22, 1977, in Utah, USA, he established himself in the tech world before pivoting his focus entirely to biological optimization.

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Johnson’s first major success came with the founding of Braintree, an online payment processing company. He sold Braintree to PayPal in 2013 for a staggering $800 million in cash, a deal that cemented his status as a major player in the venture capital space. This financial windfall allowed him to pursue his next ambitious venture, Kernel.

Kernel is a neurotech company dedicated to building advanced, non-invasive technology to monitor and record brain activity, with the goal of treating neurological diseases and improving human cognition. His current net worth as of mid-2025 is estimated to be between $200 million and $500 million, a figure that fluctuates based on his investments in emerging technologies and his previous business exits.

Johnson’s personal life has been largely subsumed by Project Blueprint, with his entire existence dedicated to the protocol. He views his body as a system to be optimized, prioritizing biological age reversal over all other aspects of traditional life.

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The 2025 Blueprint Protocol: Latest Supplement and Lifestyle Changes

Project Blueprint is a comprehensive, data-driven system designed to achieve optimal health for every one of Johnson's 78 organs. The regimen is constantly refined, and his 2025 protocol shows significant evolution from previous iterations, demonstrating a commitment to continuous, science-backed improvement.

One of the most notable 2025 updates involves his supplement and pharmaceutical stack. Johnson has openly shared his precise dosages, which include a mix of prescription drugs and nutraceuticals aimed at various longevity pathways.

Key Pharmaceuticals and Supplements (2025 Stack):

• Acarbose (200 mg Daily): A diabetes drug used off-label for its potential longevity benefits by inhibiting carbohydrate digestion.
• Tadalafil (2.5 mg Daily): A PDE5 inhibitor, commonly known as Cialis, used to promote vasodilation and blood flow, improving cardiovascular health.
• Candesartan (8 mg Daily): A blood pressure medication used to protect the kidneys and heart.
• Jardiance (10 mg Daily): Another diabetes drug (SGLT2 inhibitor) that has shown promise in improving heart and kidney function, a common theme in his stack.
• Low-Dose Lithium: A new addition to his stack in 2025, added for its neuroprotective and potential mood-stabilizing effects.
• NMN (Nicotinamide Mononucleotide): A precursor to NAD+, which is crucial for cellular energy. Johnson reduced its frequency to six days per week.
• Rapamycin (Dropped): Previously a core part of his regimen, Johnson dropped this powerful anti-aging drug in his latest protocol, likely due to updated data or side effect profiles.

Beyond the chemical stack, Johnson’s lifestyle protocols are equally stringent, focusing on maximizing the efficiency of his daily routine. He adheres to a Blueprint-like diet where every calorie is meticulously chosen for its nutritional density, following a "survival of the fittest" mentality for food. His diet is entirely plant-based and calorie-restricted, a foundational pillar of his longevity strategy.

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The Extreme Discipline: Exercise, Measurement, and Media Domination

The anti-aging experiment is not just about pills; it’s a commitment to extreme physical and cognitive discipline. Johnson dedicates approximately six hours a week to exercise, which is carefully balanced between strength training, cardiovascular work, and flexibility. A key part of his movement protocol is to be active for 5–10 minutes after every meal and to get up from his desk every 30 minutes to move around, combating the negative effects of a sedentary lifestyle.

Crucially, the entire Blueprint project is driven by measurement. Johnson uses a battery of advanced diagnostic tools, including MRI scans, DEXA scans, and blood tests, to quantify the health of his organs and track his biological age versus his chronological age. His goal is to demonstrate that a human can achieve the biological health of someone decades younger, with his latest results showing a significant reversal in the age of his skin, heart, and lungs.

The 2025 Media Blitz: 'Don't Die'

The impact of Project Blueprint transcended the biohacking community in 2025 with a major media push designed to bring the longevity discussion to the mainstream. The release of the Netflix documentary, 'Don't Die: The Man Who Wants to Live Forever', provided an intense, deep look into his highly regimented life. Directed by Chris Smith, the film showcases the true story behind his war on aging, raising ethical questions about the pursuit of eternal life.

Simultaneously, Johnson released his book, also titled 'Don't Die', which serves as a manifesto for his belief that technology can and should be used to improve human health beyond current limits. Through these platforms, he argues that the human body is a system that can be optimized and that death is an engineering problem to be solved, not an inevitability to be accepted.

Bryan Johnson’s Project Blueprint continues to evolve, pushing the boundaries of what is possible in human longevity. While critics question the sustainability and accessibility of his $2 million-a-year experiment, his detailed, open-source approach provides a wealth of data for the scientific community, making him the most transparent and perhaps the most valuable bio-optimization pioneer of the modern era.