The Hollywood GLP-1 Secret: 15+ Celebrities Who Admitted To Using Ozempic, Wegovy, And Mounjaro

The conversation around Hollywood weight loss has been irrevocably changed by a class of medications originally developed for Type 2 diabetes. As of late 2024 and early 2025, the use of GLP-1 receptor agonists—better known by brand names like Ozempic, Wegovy, Mounjaro, and Zepbound—has become arguably the industry's worst-kept secret, sparking a global debate on body image, health, and pharmaceutical ethics. This deep dive reveals the A-list stars who have confirmed their usage, the science behind the rapid transformation, and the ethical storm that continues to swirl around the "Hollywood slimming shot."

The sheer speed and dramatic nature of the weight loss experienced by some of the world’s most recognizable faces have fueled intense curiosity. While many celebrities remain silent, a growing number of influential figures are choosing to speak out, providing a candid glimpse into the pressures of maintaining a public image and the powerful efficacy of these new anti-obesity medications (AOMs).

The A-List Dossier: Celebrities Who Have Confirmed GLP-1 Use

The list of public figures who have openly discussed their experience with semaglutide (Ozempic/Wegovy) or tirzepatide (Mounjaro/Zepbound) is constantly growing. Their admissions have shifted the narrative from quiet speculation to open discussion about pharmaceutical intervention in weight management. Below is a comprehensive list of high-profile individuals who have confirmed or strongly implied their use of these medications:

• Oprah Winfrey: The media mogul and long-time public figure in the weight loss journey confirmed in December 2023 that she uses a weight-loss medication, which she later clarified was part of her health regimen. Her acknowledgment was perhaps the most significant cultural endorsement of the drugs to date.
• Amy Schumer: The comedian was one of the first to speak out, confirming she tried Ozempic but stopped due to severe side effects, including intense nausea. She has been vocal about the pressure on women in Hollywood.
• Sharon Osbourne: The television personality was very open about her use of the drug, stating she lost 42 pounds but felt constantly nauseous. She has since warned others about the extreme weight loss and difficulty maintaining it after stopping.
• Rebel Wilson: The actress confirmed she used a GLP-1 drug as part of her weight loss journey, initially referring to it as an "appetite suppressant" before specifying the class of medication. She has also discussed the rebound effect after discontinuing use.
• Chrissy Teigen: In a candid discussion, Teigen confirmed she used a different brand, likely Wegovy, for about a year following a personal loss, noting the drug helped her overcome emotional eating patterns.
• Kathy Bates: The Oscar-winning actress revealed she used Ozempic to help her lose 20 pounds, crediting it as a helpful tool alongside diet and exercise changes she had already made.
• Tracy Morgan: The comedian and actor confirmed his doctor prescribed him Ozempic, joking that he now uses it "every Thursday."
• Chelsea Handler: The comedian admitted her doctor had prescribed it without her knowing it was Ozempic, which she promptly stopped once she realized what she was taking, highlighting the casual way the drug was being prescribed.
• Lizzo: In late 2024, the singer became the latest celebrity to speak openly about the use of GLP-1s, addressing fan speculation and the public scrutiny of her body.

Other notable figures who have been rumored or have spoken about the drugs include Scott Disick, Whoopi Goldberg, and Meghan Trainor, though their confirmed usage status is less definitive or has been denied.

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The Science Behind the Transformation: Ozempic vs. Wegovy vs. Mounjaro

To understand why these drugs have caused such a sensation, it is crucial to know how they work and how they differ. The term "Ozempic" has become a catch-all for an entire class of powerful anti-obesity medications (AOMs).

The Semaglutide Family (Ozempic & Wegovy)

Both Ozempic and Wegovy contain the active ingredient semaglutide and are manufactured by Novo Nordisk.

• Mechanism: Semaglutide is a GLP-1 receptor agonist (Glucagon-like peptide-1). This synthetic hormone works in three primary ways: it stimulates the pancreas to release more insulin after a meal, prevents the liver from creating too much sugar, and, most importantly for weight loss, it slows gastric emptying and curbs appetite by signaling to the brain that the stomach is full.
• Difference: The main difference is the intended use and dosage. Ozempic is FDA-approved for Type 2 diabetes management, while Wegovy is approved specifically for chronic weight management in adults with obesity or those who are overweight with at least one weight-related condition. They are the same drug but in different dosages.

The Tirzepatide Family (Mounjaro & Zepbound)

Mounjaro and Zepbound are the newer generation drugs, both containing the active ingredient tirzepatide and manufactured by Eli Lily.

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• Mechanism: Tirzepatide is a dual-agonist, meaning it activates both the GLP-1 receptor and the GIP receptor (Glucose-dependent insulinotropic polypeptide). This dual-action mechanism is thought to make it even more effective for weight loss than semaglutide alone, leading to potentially greater weight reduction.
• Difference: Similar to the semaglutide family, Mounjaro is approved for Type 2 diabetes, and Zepbound is approved for chronic weight management.

The Controversial Aftermath: 'Ozempic Face' and Ethical Concerns

The rapid rise of GLP-1 drugs in Hollywood has not been without significant controversy, creating a complex debate that touches on ethics, health equality, and the aesthetics of rapid weight loss.

The 'Ozempic Face' Phenomenon

One highly discussed aesthetic side effect is the so-called "Ozempic Face." This term describes the facial changes that can accompany rapid, significant weight loss, regardless of the method.

• What it is: When a person loses a large amount of weight quickly, the fat pads in the face—which provide volume and structure—shrink. This can lead to a sunken, gaunt, or hollowed appearance, often resulting in sagging skin, increased wrinkles, and a look of premature aging.
• Medical Term: Dermatologists and plastic surgeons note that this is a recognized medical phenomenon called facial lipoatrophy, which is simply the natural result of fat loss in the face. It is not unique to Ozempic but is amplified by the drug's ability to facilitate rapid weight reduction.

The Ethical Storm: Shortages and Off-Label Use

The core of the ethical controversy lies in the drugs' original purpose. Ozempic and Mounjaro were developed to treat Type 2 diabetes, a serious chronic condition.

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• Drug Shortages: The immense demand driven by off-label prescribing for cosmetic weight loss—often fueled by celebrity endorsements and social media trends—has led to documented supply shortages. This shortage directly impacts diabetic patients who rely on the medication for blood sugar control, raising serious concerns about health equity.
• Off-Label Prescribing: While prescribing Ozempic for weight loss is technically legal ("off-label" use), the practice has been scrutinized, especially when prescribed to individuals who are not clinically obese or overweight, diverting supply from those with a medical necessity.
• Fat-Phobia and Societal Pressure: Critics argue that the celebrity embrace of these drugs reinforces unrealistic beauty standards and societal fat-phobia, placing immense pressure on ordinary people to achieve an "Ozempic body."

Ultimately, the GLP-1 class of drugs represents a genuine medical breakthrough in the treatment of obesity, a complex chronic disease. However, their adoption by the world's most visible figures has turned a clinical discussion into a cultural phenomenon. As more celebrities speak out—both celebrating their results and warning of the side effects like nausea and the "Ozempic Face"—the public remains captivated by the potent, yet controversial, power of the Hollywood slimming shot.