The ER Cast: Where Are They Now In 2025? Shocking Reunions And New Blockbuster Projects

The iconic medical drama *ER* continues to hold a powerful grip on pop culture, even years after its finale, and the year 2025 has brought some truly fresh and exciting updates for fans. Just recently, the world buzzed with news of a surprise reunion, proving the bonds forged at the fictional County General Hospital are as strong as ever. This article dives deep into the current lives and professional endeavors of the core cast, from blockbuster directors and major Broadway stars to new medical dramas and directorial debuts, ensuring you have the most current and unique information available today, December 12, 2025. The legacy of the groundbreaking Chicago-based medical procedural, which ran for 15 seasons, is defined by its ensemble of talented actors. The latest news confirms that these stars are not just resting on their Emmy-winning laurels; they are dominating the entertainment landscape with major projects across film, television, and theater.

The Original ER Cast: A Complete Biography and Character List

The core ensemble of *ER* launched the careers of many Hollywood heavyweights. Here is a look at the main cast members who defined the show, their iconic roles, and their key biographical details.

• George Clooney (Dr. Doug Ross): Born May 6, 1961, in Lexington, Kentucky. Role: Charismatic, often rebellious Pediatrician. Post-*ER* Career: Two-time Oscar winner (acting and producing), celebrated director, and global humanitarian.
• Julianna Margulies (Nurse Carol Hathaway): Born June 8, 1966, in Spring Valley, New York. Role: Head Nurse and Dr. Ross’s long-time love interest. Post-*ER* Career: Golden Globe and Emmy winner for *The Good Wife* and *The Morning Show*.
• Anthony Edwards (Dr. Mark Greene): Born July 19, 1962, in Santa Barbara, California. Role: The show’s moral center, an emergency medicine physician. Post-*ER* Career: Actor, director, and producer, notably in *Zodiac* and *Designated Survivor*.
• Noah Wyle (Dr. John Carter): Born June 4, 1971, in Hollywood, California. Role: The long-running character who began as a medical student and rose to become an attending physician. Post-*ER* Career: Star of *Falling Skies* and *The Librarians*, and current lead in a new medical drama.
• Eriq La Salle (Dr. Peter Benton): Born July 23, 1962, in Hartford, Connecticut. Role: The dedicated, brilliant, and intense surgical resident/attending. Post-*ER* Career: Successful director and producer, working on series like *Chicago P.D.* and *Under the Dome*.
• Sherry Stringfield (Dr. Susan Lewis): Born June 24, 1967, in Colorado Springs, Colorado. Role: An emergency medicine physician known for her complex personal life and friendship with Dr. Greene. Post-*ER* Career: Appeared in various TV and film roles.
• Gloria Reuben (Jeanie Boulet): Born June 6, 1964, in Toronto, Canada. Role: A physician assistant, notable for her HIV storyline. Post-*ER* Career: Starred in *Mr. Robot* and *City on a Hill*, and is a respected singer.

The April 2025 Reunion: County General’s Finest Together Again

In a moment that thrilled *ER* fans worldwide, four of the original core cast members—George Clooney, Julianna Margulies, Noah Wyle, and Anthony Edwards—reunited in early April 2025. The occasion was a special one: supporting George Clooney’s Broadway debut. The sight of Dr. Doug Ross, Nurse Carol Hathaway, Dr. John Carter, and Dr. Mark Greene together again sparked immediate nostalgia. This impromptu gathering quickly became a viral sensation, reminding everyone of the show’s enduring popularity and the real-life friendships that continued long after the final episode aired in 2009. This event also reignited the persistent fan speculation about an *ER* revival, a topic that has been frequently addressed by the cast in recent years. The reunion provided a perfect snapshot of the actors' current status: all are still highly active and successful in their respective careers, making the jump from the emergency room to the biggest stages in entertainment. The picture shared online was a powerful testament to the legacy of the show and its talented ensemble.

The ER Cast Now: Major 2025 Projects on Screen and Stage

The cast of *ER* has transitioned successfully into major post-show careers, with 2025 proving to be a particularly busy year for several key players. Their current endeavors highlight their versatility, moving beyond the medical procedural genre that made them household names.

George Clooney: From Dr. Ross to Jay Kelly and Broadway

George Clooney has long been one of the biggest movie stars in the world, and 2025 sees him continuing his high-profile run. In addition to his aforementioned Broadway debut, Clooney is starring in the new comedy-drama film *Jay Kelly*, alongside Adam Sandler. Directed by Noah Baumbach, the movie is a major streaming event, showcasing Clooney’s enduring appeal in the film industry. His work as a director and producer also continues to thrive, cementing his status as a Hollywood powerhouse.

Noah Wyle: Back to the Medical World in The Pitt

Noah Wyle, who holds the distinction of appearing in the most *ER* episodes as Dr. John Carter, is back in the world of high-stakes medicine, albeit in a different role. Wyle is starring in the new medical drama *The Pitt*, which has garnered significant attention in 2025. The series, which focuses on the intense environment of a Pittsburgh hospital, has already seen Wyle take on directing duties for upcoming episodes, showcasing his growth from a young actor to a seasoned creative force. Wyle has also been one of the main voices discussing the possibility of an *ER* revival, keeping the hope alive for fans of the original.

Julianna Margulies: The Stage and The Screen

Julianna Margulies, the Emmy-winning star who played Nurse Carol Hathaway, is dividing her time between film and stage in 2025. She is part of the cast of Edward Burns' new film, *Millers in Marriage*. Furthermore, Margulies is starring in the new Broadway play *Left on Tenth*, based on Delia Ephron’s bestselling memoir, directed by five-time Tony Award winner Susan Stroman. Her recent television work on critically acclaimed series like *The Morning Show* and *Billions* also keeps her profile incredibly high.

Eriq La Salle: Directing and Starring in On Call

Eriq La Salle, known as the formidable Dr. Peter Benton, has established himself as a prolific director and producer in television. In 2025, he is executive producing, directing, and starring in the new police drama *On Call* on Prime Video. La Salle’s involvement as a lead actor in the series, which follows a rookie and veteran police duo, marks a significant return to a major on-screen role while continuing his successful work behind the camera. His career trajectory is a prime example of an *ER* star leveraging their success to gain creative control in Hollywood.

The Enduring Legacy of the ER Medical Drama

The success of *ER* was not just due to its compelling storylines about trauma and emergency medicine; it was the phenomenal chemistry and talent of its cast. Entities like Laura Innes (Dr. Kerry Weaver), Maura Tierney (Abby Lockhart), Alex Kingston (Dr. Elizabeth Corday), Mekhi Phifer (Dr. Gregory Pratt), and Linda Cardellini (Samantha Taggart) all contributed to the show's rich tapestry over its long run. The recent 2025 reunion and the high-profile projects of the core cast members—from Clooney’s film work to Wyle’s new medical drama *The Pitt*—demonstrate that the stars of County General Hospital are far from finished. They continue to shape the landscape of television and film, carrying the legacy of the show forward into a new generation of entertainment. The speculation about a potential *ER* revival, fueled by the cast's continued closeness and professional success, ensures that the spirit of the groundbreaking medical procedural remains alive and well.