The Explosive Despicable Me 4 Cast: 10 Major Stars Joining Gru’s Biggest Adventure Yet

The Despicable Me universe is set for its most ambitious expansion yet, and as of December 18, 2025, the confirmed cast list for Despicable Me 4 is a blockbuster lineup that promises to deliver the franchise's signature blend of heart and hilarious chaos. Illumination's latest installment is not just bringing back the beloved core family—Gru, Lucy, and the girls—but is also introducing a host of A-list talent to voice a new nemesis and other key characters, ensuring the fourth film feels fresh, exciting, and absolutely unmissable when it hits theaters.

This comprehensive guide dives deep into every confirmed voice actor, from the returning veterans who define the franchise to the exciting newcomers who are set to challenge Gru's newfound domestic bliss. Get ready to meet the new villain, his formidable girlfriend, and the adorable new member of the Gru family, Gru Jr., as we break down the full, star-studded cast that will bring this highly anticipated animated comedy to life.

The Full Roster: Every Confirmed Voice Actor and Character

The foundation of the Despicable Me franchise lies in its stellar and consistent voice cast, and Despicable Me 4 sees the return of all the fan favorites. However, the biggest buzz surrounds the incredible roster of new talent joining the ranks, including comedy legends and Emmy winners, who are poised to shake up Gru's world.

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• Steve Carell as Gru: The former supervillain turned Anti-Villain League (AVL) agent and family man. Carell returns to voice the central, lovable character with his distinct, quirky accent.
• Kristen Wiig as Lucy Wilde: Gru’s wife, a fellow AVL agent, and a dedicated, if somewhat eccentric, mother to the girls. Wiig’s energetic performance is a cornerstone of the series.
• Miranda Cosgrove as Margo: The eldest and most responsible of the three adopted daughters. Cosgrove has voiced Margo since the very first film.
• Dana Gaier as Edith: The middle adopted daughter, known for her tomboyish and mischievous nature.
• Madison Polan as Agnes: The youngest and most innocent of the girls, obsessed with unicorns. Polan takes over the role, replacing Nev Scharrel from the third film.
• Pierre Coffin as The Minions: The iconic, gibberish-speaking yellow henchmen, including fan favorites like Kevin, Stuart, and Bob. Coffin voices all the Minions, maintaining their unique charm.
• Will Ferrell as Maxime Le Mal: The film's new primary antagonist, a formidable and stylish supervillain who escapes from prison and seeks revenge on Gru.
• Sofía Vergara as Valentina: Maxime Le Mal’s femme fatale girlfriend and partner in crime. Vergara’s casting brings a high-profile, fresh dynamic to the villainous duo.
• Joey King as Poppy Prescott: A new, significant character whose role is tied to Gru's mission. She is a fledgling villain who idolizes Gru and is a key figure in the plot.
• Stephen Colbert as Perry Prescott: The father of Poppy Prescott and a character whose connection to the plot is a closely guarded secret, adding an element of mystery.
• Chloe Fineman as Melinda: A new character voiced by the Saturday Night Live star, though specific details about her role are yet to be fully revealed.
• Chris Renaud as Gru Jr.: Gru and Lucy’s biological son, introduced in this film. Renaud, who also co-directs, lends his voice to the newest, adorable member of the family.
• Steve Coogan as Silas Ramsbottom: The former director of the Anti-Villain League, whose return suggests an ongoing role in Gru’s professional life.

New Villains and Fresh Faces: Meet the Star-Studded Additions

The true excitement for Despicable Me 4 lies in its phenomenal new voice cast, which elevates the film’s star power considerably. The addition of these comedic powerhouses ensures the new characters are instantly memorable and provide a worthy challenge to Gru and his family.

The headline-grabbing addition is Will Ferrell as Maxime Le Mal. Ferrell, a legendary figure in comedy, brings his unique, over-the-top energy to Gru's new nemesis. Maxime Le Mal is a supervillain with a stylish flair and a deep-seated grudge against Gru. The conflict is personal, as Gru and his family are forced to go on the run after Maxime escapes from prison, setting the stage for a high-stakes, international chase.

Joining Ferrell is the equally charismatic Sofía Vergara as Valentina, Maxime Le Mal's girlfriend. Valentina is described as a femme fatale, a perfect foil to Lucy Wilde, and a key player in Maxime's revenge plot. The dynamic between Ferrell and Vergara is expected to be a comedic highlight, offering a fresh, sophisticated villainous duo that the franchise has not seen before.

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Another major addition is Joey King, who voices Poppy Prescott. Poppy is not just a side character; she is a budding villain who idolizes Gru, the man who was once the world's greatest criminal. Her admiration for Gru's past makes her a complicated figure in his present life as an AVL agent. King's character is crucial, as she forms an alliance with Gru to help him and the Minions on their mission.

Rounding out the new, high-profile cast are Stephen Colbert and Chloe Fineman. Colbert voices Poppy's father, Perry Prescott, a character whose full involvement remains mysterious but is certainly a source of potential conflict or assistance. Fineman's character, Melinda, adds another layer of comedic talent to the ensemble, promising plenty of laughs alongside the returning Minions.

The Plot Thickens: Gru's New Life, Gru Jr., and the Super Minions

Beyond the star-studded cast, the plot of Despicable Me 4 introduces several major developments that fundamentally change Gru's life and the trajectory of the franchise. The central theme revolves around Gru’s transition into a full-fledged family man while balancing his duties as an Anti-Villain League agent.

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The Arrival of Gru Jr.

The biggest and most adorable change is the introduction of Gru and Lucy's biological son, Gru Jr. Voiced by co-director Chris Renaud, Gru Jr. is a source of both immense joy and new challenges for the family. The film's synopsis confirms that the entire Gru family—Gru, Lucy, Margo, Edith, and Agnes—are welcoming this new member. Gru Jr. is depicted as a baby who is constantly giving his father a hard time, adding a layer of relatable, domestic comedy to Gru's already chaotic life.

The Threat of Maxime Le Mal and Valentina

The central conflict is driven by the escape and revenge plot of Maxime Le Mal. Gru's past as a supervillain comes back to haunt him when Maxime and Valentina target his family. This threat is so severe that the entire Gru family is forced to go on the run and enter a witness protection-style program, relocating to a new, safe house. This premise offers a fresh take on the 'family on the run' trope, allowing for new environments, challenges, and comedic scenarios.

The Minions Develop Super-Powers

In a thrilling twist revealed in the latest trailers, a select group of Minions—including Kevin, Stuart, and Bob—are given a special serum by the AVL that grants them super-powers. These "Mega Minions" are a major plot device, transforming the tiny yellow sidekicks into powerful, if still clumsy, superheroes. This development is a massive injection of fresh, action-comedy material, promising spectacular new visual gags and high-stakes action sequences that the Minions have never been capable of before.

The combination of a personal vendetta from Maxime Le Mal, the logistical nightmare of protecting a new baby (Gru Jr.), and the unpredictable chaos of the super-powered Minions creates a perfect storm for Gru's latest adventure. The film promises a high-octane mix of family drama, spy action, and signature Illumination comedy.

Topical Authority: The Legacy and Future of the Despicable Me Franchise

Despicable Me 4 is not just another sequel; it is the sixth film in a cinematic universe that has grossed billions worldwide, including the highly successful Minions spin-off films. The decision to bring back original director Chris Renaud and screenwriter Ken Daurio, coupled with the addition of The White Lotus creator Mike White as a co-writer, signals a commitment to maintaining the franchise's emotional core while injecting fresh, contemporary humor.

The film delves deeper into Gru’s role as an Anti-Villain League agent, a career path that began in Despicable Me 2. The inclusion of new characters like Joey King's Poppy Prescott, an aspiring villain, allows the film to explore the moral grey areas of Gru's past and how his legacy is viewed by the next generation of criminals. This focus on "topical authority" ensures the film is not just a rehash but a genuine continuation of Gru’s complex journey from supervillain to super-spy and super-dad.

With a confirmed release date in 2024, the anticipation for this latest installment is at an all-time high. The carefully curated cast, featuring a blend of returning favorites and new, high-caliber talent like Will Ferrell and Sofía Vergara, suggests that Illumination is pulling out all the stops to make Despicable Me 4 a landmark event in animated cinema.

The film is set to explore new themes of family protection, the struggle of parenthood, and the unexpected consequences of Minions with super-powers, guaranteeing a fresh and hilarious cinematic experience that will delight both long-time fans and new audiences alike. Get ready to say "Bello!" to the biggest, best, and most star-studded Despicable Me adventure yet.