10 Famous Celebrities Who Are Fighting Multiple Sclerosis (MS) In 2025: The Latest Updates On Their Courageous Journeys

The world of Hollywood and professional sports is often seen as a place of effortless glamour and peak performance, but behind the curtain, many famous figures are navigating the daily, unpredictable challenges of Multiple Sclerosis (MS). As of late 2025, these celebrities are not just managing a chronic, often debilitating autoimmune disease; they are transforming their diagnoses into powerful platforms for awareness, research, and hope, offering candid and often raw updates on their health journeys.

The courage shown by these public figures in discussing their symptoms—from debilitating fatigue and mobility issues to cognitive challenges—has fundamentally shifted the public dialogue around MS. This article provides the most current, fresh updates on the health and advocacy work of the most famous celebrities living with MS, highlighting their resilience and the latest developments in their lives and careers.

Christina Applegate: A Candid Look at Her MS Journey

Christina Applegate, the beloved actress known for her roles in Married... with Children, Samantha Who?, and the critically acclaimed Netflix series Dead to Me, has been incredibly transparent about her life since her diagnosis with Multiple Sclerosis in August 2021. Her openness has made her one of the most visible and relatable advocates for the MS community.

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Biography and Career Highlights

• Full Name: Christina Applegate
• Born: November 25, 1971 (Age 54 as of late 2025)
• Birthplace: Hollywood, California, U.S.
• Career: Actress, Dancer, Producer
• Notable Roles: Kelly Bundy (Married... with Children), Sue Ellen Crandell (Don't Tell Mom the Babysitter's Dead), Veronica Corningstone (Anchorman), Jen Harding (Dead to Me).
• MS Diagnosis: Announced in August 2021, diagnosed a few months prior.
• Key Awards: Primetime Emmy Award, multiple Screen Actors Guild Award nominations, Tony Award nomination.

Latest Health Updates and Advocacy

Applegate has consistently provided frank and often heartbreaking updates on her health, detailing the reality of living with MS. She has spoken openly about experiencing significant flare-ups and the necessity of using a cane or wheelchair for mobility.

In recent interviews, she revealed the intense medical journey she's undergone, including being hospitalized upwards of 30 times for various tests since her diagnosis. Her decision to attend major industry events, such as the Screen Actors Guild Awards, with a cane and the support of her daughter, Sadie Grace LeNoble, has been a powerful statement about visibility and acceptance.

Her advocacy is centered on honesty, focusing on the mental and physical toll of the disease, which affects the central nervous system. She continues to be a source of strength for others facing similar challenges, using her platform to ensure the conversation around chronic illness remains current and uncensored.

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Selma Blair: Regaining Stamina and Finding Joy

Selma Blair, known for her roles in films like Cruel Intentions and Legally Blonde, was diagnosed with MS in 2018. Her journey has been documented with exceptional grace, notably in her 2021 documentary, Introducing, Selma Blair, which offered an intimate look at her stem cell transplant treatment.

In the most recent updates, Blair has shared positive news regarding her health, specifically noting that she feels like she is regaining her stamina. This is a significant milestone, as debilitating fatigue is one of the most common and challenging symptoms of MS. She has expressed gratitude for the progress she has made since first learning of her condition and continues to inspire with her optimistic outlook and dedication to physical therapy and self-care.

Blair’s presence on social media and in public forums is a beacon of hope, showing that even with a chronic, progressive disease, it is possible to find moments of joy and reclaim physical capabilities. Her focus on mobility and quality of life is a major point of topical authority for the MS community.

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The New Faces of MS Advocacy: Jamie-Lynn Sigler and Jack Osbourne

The conversation around Multiple Sclerosis is continually evolving, thanks to a new generation of advocates who are using their celebrity to normalize the condition.

Jamie-Lynn Sigler: Bringing MS to the Screen

Jamie-Lynn Sigler, best known as Meadow Soprano from The Sopranos, was diagnosed with MS at age 20 but kept it private for many years before publicly announcing it in 2016. Her latest career move is a powerful step in MS representation: she is set to guest star on Grey's Anatomy as Dr. Laura Kaplan, a urologist who is also living with MS.

This role is groundbreaking because it moves beyond the typical narrative of MS as solely a tragic or debilitating condition, instead portraying a character who is a successful, practicing physician managing her condition. Sigler’s decision to take on a role that mirrors her own battle with the neurological disease is a testament to her commitment to authentic representation and is a major update for 2025.

Jack Osbourne: Discussing Alternative Treatments

Jack Osbourne, son of rock legend Ozzy Osbourne and reality TV star, was diagnosed with Relapsing-Remitting Multiple Sclerosis (RRMS) in 2012 at the age of 26. He has become a prominent voice for younger individuals facing the diagnosis.

Osbourne has been candid about the professional challenges he faced, including losing work because he was deemed an "insurance risk" after his diagnosis. However, he reports that he is currently "doing very well with my MS" and has been openly discussing his use of "alternative" treatments alongside conventional disease-modifying therapies (DMTs). His advocacy focuses on managing the disease proactively and raising awareness through the National MS Society.

More Famous Figures and Their Fight Against MS

The list of influential people who have publicly shared their MS diagnosis is extensive, demonstrating that the disease affects people across all industries and walks of life. Their stories contribute to a greater understanding of the different types of MS and the diverse range of symptoms, such as optic neuritis, numbness, and oligoclonal bands (OCBs) found in spinal fluid, which are indicators of central nervous system inflammation.

• Montel Williams: The former talk show host was diagnosed in 1999 with MS. He has become one of the most vocal and long-standing advocates, establishing the Montel Williams Foundation to fund research and raise awareness.
• John King: The CNN Chief National Correspondent revealed his diagnosis in 2021. His public announcement highlighted the fact that MS is an unpredictable disease that can affect anyone, regardless of their high-pressure career.
• Emma Caulfield Ford: Known for her roles in Buffy the Vampire Slayer and WandaVision, Ford revealed her diagnosis in 2022. As of a March 2024 interview, she shared a positive update: her symptoms remain mild, and MRI scans have not shown any significant disease progression, a hopeful sign for those with less aggressive forms of the disease.
• Art Alexakis: The lead singer of the rock band Everclear announced his MS diagnosis in 2019. He continues to tour and create music, demonstrating that a diagnosis does not have to mean the end of a creative career.
• Trevor Bayne: A professional NASCAR driver, Bayne was diagnosed with MS in 2011 at a young age. He has continued his racing career while managing his condition, particularly focusing on the role of diet and exercise.
• Chris Wright: The first professional basketball player to play in the NBA with Multiple Sclerosis. His story highlights the challenges athletes face when managing MS symptoms like muscle weakness and fatigue on the court.
• Kadeena Cox MBE: A British Paralympic champion in both cycling and athletics, Cox was diagnosed with MS in 2014. She has won multiple gold medals, famously stating that "MS doesn't put a full stop after your name," proving that elite athletic performance is still possible.

The Impact of Celebrity Advocacy on MS Awareness and Research

The collective voices of these celebrities have a profound impact, moving the conversation beyond the clinical definitions of the disease—such as the difference between Relapsing-Remitting MS (RRMS), Secondary Progressive MS (SPMS), and Primary Progressive MS (PPMS)—and into the realm of real-world experience. Their personal stories help to destigmatize the use of mobility aids and open discussions about the invisible symptoms of MS, like chronic pain, brain fog, and the emotional toll on quality of life.

By sharing their experiences with treatments, including disease-modifying therapies (DMTs), stem cell transplants, and even alternative approaches like managing neuroinflammation through diet, they provide a valuable, accessible resource for newly diagnosed patients. Their transparency encourages funding for critical research into biomarkers and the underlying causes of MS, ensuring that the search for a cure remains a global priority.

Ultimately, these famous figures are not just survivors; they are powerful agents of change. Their ongoing, public battles with Multiple Sclerosis in 2025 serve as a powerful reminder that while the disease is a challenge, it is not a defining characteristic. Their resilience is an inspiration to millions worldwide who are navigating their own chronic health journeys.