The Final Pubescent Hurrah: Everything We Know About The BIG MOUTH Season 8 Cast And The End Of An Era

The highly-anticipated final season of Netflix's groundbreaking animated comedy, *Big Mouth*, is officially on the horizon, promising a massive send-off for its beloved, hormone-addled characters. As of December 2025, the confirmed cast list for Season 8 reveals a spectacular return of the core ensemble alongside an exciting roster of new and familiar guest voices, all set to deliver one last, hilariously gross chapter in the lives of Nick, Andrew, Jessi, and their monstrous guides. This final installment, slated for a May 23, 2025 release, is not just a conclusion; it’s a full-circle moment where the show’s creators bring back fan-favorite actors and introduce key new entities like the 'Compassion Hormone Monster' to guide the kids through their last stages of puberty before they head to high school. The upcoming eighth and final season will see the kids face the daunting transition from middle school to high school, a perfect narrative device to explore new anxieties, new body-image issues, and, inevitably, new Hormone Monsters. The show's creators, Nick Kroll and Andrew Goldberg, have promised a heartfelt, yet characteristically crude, farewell, ensuring that the legacy of this Emmy Award-winning adult animated sitcom is cemented in television history.

The Core Voice Cast: A Full Profile of Returning Stars

The heart and soul of *Big Mouth* have always been its incredibly talented and versatile voice actors, many of whom also serve as the show's creators and writers. Season 8 sees the full return of this main cast, reprising their roles as both the human protagonists and the fantastical creatures that embody their puberty struggles. * Nick Kroll: * Characters: Nick Birch, Maury the Hormone Monster, Coach Steve, Rick the Hormone Monster, Lola Skumpy. * Profile: Co-creator, executive producer, and writer. A comedian and actor known for *The Kroll Show* and his diverse voice work. * John Mulaney: * Characters: Andrew Glouberman, Mint. * Profile: Comedian, actor, and writer, famous for his stand-up specials and his time as a writer on *Saturday Night Live*. Andrew is Nick's best friend and co-lead. * Jessi Klein: * Character: Jessi Glaser. * Profile: Comedian, actress, and author. She is a former head writer for *Inside Amy Schumer*. Jessi is one of the main female protagonists. * Ayo Edebiri: * Character: Missy Foreman-Greenwald. * Profile: Comedian, actress, and writer, known for her roles in *The Bear* and *Bottoms*. She took over the role of Missy in Season 4. * Jason Mantzoukas: * Character: Jay Bilzerian. * Profile: Comedian, actor, and writer, known for his roles in *The League* and *Brooklyn Nine-Nine*. Jay is the chaotic, sexually adventurous member of the friend group. * Maya Rudolph: * Characters: Connie the Hormone Monstress, Diane Birch, Bonnie the Hormone Monstress. * Profile: Actress, comedian, and singer, known for her tenure on *Saturday Night Live*. She has won multiple Emmy Awards for her voice work on the show. * Fred Armisen: * Character: Elliot Birch (Nick's father). * Profile: Actor, comedian, and musician, known for *Saturday Night Live* and *Portlandia*. * Jordan Peele: * Character: Ghost of Duke Ellington. * Profile: Filmmaker, actor, and comedian, known for *Key & Peele* and his directorial work on *Get Out* and *Nope*. * Andrew Rannells: * Character: Matthew MacDell. * Profile: Actor and singer, known for his roles in *The Book of Mormon* and *Girls*. Matthew is one of the main supporting characters.

New Entities and Star-Studded Guest Voices Joining The Final Chapter

True to form, *Big Mouth* Season 8 is not shy about introducing new, absurdly specific entities to personify the kids' evolving emotional and physical challenges. The final season has lined up a formidable list of guest stars, bringing fresh voices to the show's unique mythological world.

A New Hormone Monster and a Gremlin of Ambition

One of the most significant additions to the *Big Mouth* universe in its final season is the introduction of a new creature designed to tackle a more nuanced emotional state: Compassion. This character and others will help guide the main cast toward their inevitable high school graduation. * Holly Hunter as Compassion: Emmy and Oscar-winning actress Holly Hunter joins the ensemble as a brand-new Hormone Monster named Compassion. This entity is expected to bring a different kind of guidance to the students, moving beyond the raw, aggressive urges of Maury and Connie and towards a more empathetic understanding of others. * Rosie Perez as Petra the Ambition Gremlin: Known for her distinctive voice and powerful performances, Rosie Perez will voice Petra, the Ambition Gremlin. This character is likely to contrast with the Anxiety Mosquito and Depression Kitty, pushing the kids to think about their future and goals, adding a new layer to their emotional landscape.

The Final Season’s Impressive Guest Star Roster

The show’s tradition of featuring A-list talent continues for its last run, with several major names confirmed to lend their voices to various characters, from medical professionals to new teachers or even more emotional entities. * Steve Buscemi as Mr. Pink: The veteran actor, known for his distinct voice and character work, is confirmed to play Mr. Pink. The nature of this character is still under wraps, but given the show’s track record, it will likely be a memorable and eccentric role. * Cynthia Erivo as a Gynecologist: Tony and Grammy winner Cynthia Erivo will voice a Gynecologist. This character suggests that the storyline will continue to address sensitive health and sexuality topics with the show's signature blend of humor and honesty. * Billy Porter: The iconic actor and singer, known for *Pose*, is also confirmed to be a guest voice in Season 8. His role is yet to be fully detailed, but his presence guarantees a powerful performance. * Other Confirmed Cameos: The list of additional guest stars includes the comedic talents of Kristen Wiig, Ali Wong, and Chloe Fineman. Their involvement hints at more hilarious and surreal interactions that the main characters will encounter as they navigate their final middle school days.

Thematic Entities and LSI Keywords: The World of Puberty Personified

The success of *Big Mouth* lies in its ability to personify the abstract and often embarrassing concepts of puberty. Season 8 will continue to utilize its rich tapestry of thematic entities, which are crucial to the show's topical authority and emotional depth. These entities, often referred to as LSI (Latent Semantic Indexing) keywords in the context of SEO, are the backbone of the show's narrative. The returning entities are essential for the final season's storytelling. We expect to see more of the Shame Wizard (voiced by David Thewlis), the master of guilt and self-loathing, as the characters grapple with the consequences of their actions. The Anxiety Mosquito and the Depression Kitty will undoubtedly make appearances, reflecting the students' growing mental health struggles as they face major life changes, like the move to high school. The Hormone Monsters, including Maury, Connie, and Rick, will be central to the final chapter. Their over-the-top, often contradictory advice on sex, masturbation, and relationships drives much of the comedic and dramatic tension. The introduction of Compassion signifies a thematic shift, suggesting that the characters are finally learning to process their emotions with greater maturity and empathy, a fitting arc for the final season. The show's consistent use of entities like the Logic Rock, the Tito the Anxiety Mosquito, and the Lovebug (voiced by Brandon Kyle Goodman) has created a unique vocabulary for discussing the horrors and wonders of adolescence. The final season will likely give these entities their own farewell arcs, providing closure not just for the students but for the fantastical creatures that have guided them for seven seasons.

What to Expect from the Final Season 8 Storyline

The eighth season of *Big Mouth* is confirmed to be the final season and is scheduled to premiere on May 23, 2025. The overarching story will focus on the main group—Nick Birch, Andrew Glouberman, Jessi Glaser, and Missy Foreman-Greenwald—completing their middle school journey and preparing for high school. This transition is a major milestone, promising a mix of nostalgic goodbyes and terrifying new beginnings. The show has always excelled at tackling difficult and sensitive subjects, and the final season is expected to continue this trend, with storylines touching on deeper emotional maturity, identity, and the complexity of adolescent relationships. The introduction of the Gynecologist character suggests a continued focus on sexual health education, while the Compassion Hormone Monster hints at a narrative centered on emotional intelligence and kindness in a turbulent world. This final season will not only wrap up the story of *Big Mouth* but will also serve as a bridge to the spin-off series, *Human Resources*, which is also concluding. Fans are eager to see how the show manages to give a satisfying conclusion to its core characters while maintaining the outrageous, honest, and often surreal humor that has made it a cultural phenomenon. The final ten episodes will be a must-watch for anyone who has ever survived the awkward, exhilarating, and deeply confusing experience of puberty.