The Hilarious Real-Life Cast Behind Big Mouth's Puberty Chaos: Full Biographies And Season 8 Guest Stars

The Netflix animated comedy Big Mouth has brilliantly and brazenly chronicled the horrors and hilarity of puberty since 2017, culminating in its eagerly anticipated and final Season 8, which is set to conclude the main story. As of December 18, 2025, the show remains a cultural touchstone, known for its raw honesty and its stacked roster of comedic talent. The genius of the series lies not just in the writing, but in the voices of the actors—a core ensemble of comedians who often play multiple, unforgettable characters, from awkward teens to personified hormones.

This article provides an in-depth, updated look at the real-life stars who bring Nick Birch, Andrew Glouberman, Missy Foreman-Greenwald, and the entire ecosystem of emotional monsters to life, including a complete biographical profile of the main cast and a rundown of the latest celebrity cameos in the final season.

The Core Cast: Full Biography and Notable Works

The main voice actors of Big Mouth are a powerhouse of Emmy-winning writers, comedians, and producers, many of whom have worked together for years on projects like The League and Saturday Night Live. Their collective comedic history is the bedrock of the show’s success.

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• Nick Kroll (Nick Birch, Maury the Hormone Monster, Coach Steve, Lola Skumpy, Rick):
  • Born: Nicholas Kroll, June 5, 1978.
  • Role in Show: Co-creator, writer, and star. Voices the show’s protagonist, Nick Birch, and several fan-favorite entities, including the messy teenager Lola Skumpy and the often-inappropriate Coach Steve.
  • Notable Works: Starred as Ruxin on the FX comedy series The League, created and starred in Kroll Show, and appeared in films like Sing and Don't Worry Darling.
• John Mulaney (Andrew Glouberman):
  • Born: John Edmund Mulaney, August 26, 1982.
  • Role in Show: Voices Nick's best friend, Andrew Glouberman, the perpetually anxious and hormonal teen.
  • Notable Works: A highly successful stand-up comedian with specials like Kid Gorgeous and New in Town. He was also a writer for Saturday Night Live (SNL) for six seasons, where he co-created the character Stefon with Bill Hader.
• Maya Rudolph (Connie the Hormone Monstress, Diane Birch, Missi, various):
  • Born: Maya Khabira Rudolph, July 27, 1972.
  • Role in Show: The multi-Emmy-winning voice of Connie the Hormone Monstress, known for her signature catchphrase, "Bubble bath!" She also voices Nick’s mother, Diane Birch, and other characters.
  • Notable Works: A legendary cast member on Saturday Night Live from 2000 to 2007, and starred in major films like Bridesmaids, Inherent Vice, and the Apple TV+ series Loot.
• Ayo Edebiri (Missy Foreman-Greenwald):
  • Born: Ayo Edebiri, October 3, 1995.
  • Role in Show: Voices the biracial, intellectual, and increasingly complex Missy Foreman-Greenwald, a role she took over in Season 4.
  • Notable Works: A breakout star, she won an Emmy and a Golden Globe in 2024 for her role as Sydney Adamu on the hit FX series The Bear. She is also a noted writer and comedian.
• Jason Mantzoukas (Jay Bilzerian):
  • Born: December 18, 1972.
  • Role in Show: Voices the chaotic, pansexual, and often unhinged Jay Bilzerian, who has a notorious relationship with his pillow and the Hormone Monsters.
  • Notable Works: Known for his recurring role as Rafi on The League, his appearance in the film The Dictator, and numerous roles in comedy podcasts and TV shows like Brooklyn Nine-Nine.
• Jessi Klein (Jessi Glaser):
  • Born: Jessi Ruth Klein, August 18, 1975.
  • Role in Show: Voices the cynical, sardonic, and highly relatable Jessi Glaser, who experiences some of the show's most grounded emotional struggles.
  • Notable Works: An Emmy and Peabody Award-winning writer and producer, she was the head writer and executive producer for Inside Amy Schumer and is the author of the best-selling book You'll Grow Out of It.

The Major Cast Change: Ayo Edebiri Taking Over Missy

One of the most significant and celebrated casting decisions in the show’s history was the recasting of the character Missy Foreman-Greenwald. Jenny Slate, who had voiced Missy since Season 1, stepped down from the role in 2020.

Slate, who is white, made the decision because she felt a biracial character like Missy should be voiced by a Black actor. This move was part of a broader industry conversation about representation in animation.

The transition was handled cleverly within the show’s narrative. Missy’s voice begins to change in the penultimate episode of Season 4, symbolizing a pivotal moment of self-discovery and an evolution of her identity as she grapples with her Blackness and overall sense of self.

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Ayo Edebiri, a talented writer and comedian who had also joined the Big Mouth writers' room, took over the role, bringing a fresh, authentic perspective to the character. Her subsequent rise to global fame with her Golden Globe and Emmy wins for The Bear only solidified the excellent choice of the casting team.

The Expanding Universe of Emotional Entities

The world of Big Mouth extends far beyond the core group of middle schoolers, introducing a complex and hilarious bureaucracy of personified feelings and concepts. These entities—often voiced by the core cast or recurring guest stars—are key to the show’s topical authority and its universe, which was further explored in the spin-off series, Human Resources.

Key Recurring Entities and Their Voices

• Connie the Hormone Monstress (Maya Rudolph): The primary Monstress for Jessi and later Nick, known for her dramatic flair and penchant for bubble baths.
• Maury the Hormone Monster (Nick Kroll): Andrew's primary Hormone Monster, a crude but sometimes philosophical guide to puberty. He is one of the central figures in the Human Resources spin-off.
• The Shame Wizard (David Thewlis): A British-accented, glitter-throwing entity who feeds on the embarrassment of the children. His dark, theatrical presence is a stark contrast to the Hormone Monsters.
• The Depression Kitty (Jean Smart): A literal cat who embodies the crushing weight of depression, often appearing to Jessi Glaser.
• Tito the Anxiety Mosquito (Maria Bamford): A buzzing, frantic creature who personifies the overwhelming feeling of anxiety, particularly for Nick.
• Ghost of Duke Ellington (Jordan Peele): The ethereal, jazz-loving ghost who lives in Nick’s attic and offers questionable life advice.

Season 8 and Beyond: Final Season Guest Stars and The Future

As Big Mouth wraps up its run with the final Season 8, the show has continued its tradition of featuring an astonishing line-up of celebrity guest stars, adding depth and humor to the kids' final journey through adolescence. These cameos often voice new entities or one-off characters that perfectly capture a specific emotion or struggle.

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The final season’s guest stars include major names from film and television, ensuring the show goes out with a bang:

• Rosie Perez as Petra the Ambition Gremlin, a new entity guiding the characters' post-puberty drives.
• Holly Hunter as Compassion.
• Steve Buscemi as Mr. Pink.
• Cynthia Erivo, known for her roles in Wicked and Harriet, as a Gynecologist.
• Billy Porter in an unannounced role, adding another layer of star power.

While the main series concludes, the world Nick Kroll, Andrew Goldberg, and their team created lives on. The spin-off, Human Resources, which focuses entirely on the workplace of the emotional entities—including Connie, Maury, and the Shame Wizard—serves as a continuation of the Big Mouth universe. Though Human Resources has also concluded its run, its connection to the final seasons of Big Mouth solidifies the entire franchise as one of the most important and hilarious explorations of the human condition in modern adult animation.