The ER Cast Reunion And What They’re Doing Now: 15 Stars With Huge 2024/2025 Projects

The iconic cast of ER, the groundbreaking medical drama that ran for 15 seasons, continues to dominate Hollywood decades after the show’s finale. In a major and highly publicized event in April 2024, four of the original core cast members—George Clooney, Julianna Margulies, Anthony Edwards, and Noah Wyle—reunited, sparking a massive wave of nostalgia and proving the show's enduring cultural impact.

This 2025-focused update delves into the current careers of the doctors and nurses of County General Hospital, highlighting their freshest and most significant projects, from blockbuster films and new medical dramas to major roles on hit network shows. The cast members are busier than ever, ensuring the legacy of the show lives on through their individual successes.

The County General Alumni: A Complete Roster of the Core Cast

ER was a powerhouse of talent, launching the careers of several global superstars and featuring a rotating ensemble that kept the series fresh. Here is a complete look at the main actors and the characters they played, forming the backbone of one of television's most beloved dramas.

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• George Clooney (Dr. Doug Ross)
  • Biography: Born May 6, 1961, in Lexington, Kentucky. Played the charming, womanizing pediatrician from 1994 to 1999.
• Julianna Margulies (Nurse Carol Hathaway)
  • Biography: Born June 8, 1966, in Spring Valley, New York. Played the dedicated, often emotionally complex head nurse from 1994 to 2000.
• Anthony Edwards (Dr. Mark Greene)
  • Biography: Born July 19, 1962, in Santa Barbara, California. Starred as the show's initial protagonist, the compassionate, long-suffering emergency physician from 1994 to 2002.
• Noah Wyle (Dr. John Carter)
  • Biography: Born June 4, 1971, in Hollywood, California. The longest-running main cast member, portraying the medical student turned attending physician from 1994 to 2005 (with returns in later seasons).
• Eriq La Salle (Dr. Peter Benton)
  • Biography: Born July 23, 1962, in Hartford, Connecticut. Played the brilliant, demanding surgical resident and later attending from 1994 to 2002.
• Sherry Stringfield (Dr. Susan Lewis)
  • Biography: Born June 24, 1967, in Colorado Springs, Colorado. The original attending physician who had two separate runs on the show (1994–1996 and 2001–2005).
• Laura Innes (Dr. Kerry Weaver)
  • Biography: Born August 16, 1957, in Pontiac, Michigan. A series regular from 1995 to 2007, playing the ambitious, often controversial Chief of Staff.
• Maura Tierney (Dr. Abby Lockhart)
  • Biography: Born February 3, 1965, in Boston, Massachusetts. Joined in 1999 as a nurse turned medical student turned doctor, leaving in 2009.
• Goran Višnjić (Dr. Luka Kovač)
  • Biography: Born September 9, 1972, in Šibenik, Croatia. Joined the cast in 1999 as the Croatian physician who eventually marries Carol Hathaway.
• Mekhi Phifer (Dr. Gregory Pratt)
  • Biography: Born December 29, 1974, in Harlem, New York. Played the talented but rebellious doctor from 2002 to 2008.

From County General to the Big Screen: Where the Stars Are Now

The success of ER was a launchpad, and its cast members have maintained impressive careers in film, television, and even behind the camera. Here is the latest on the most prominent alumni, with a focus on their 2024 and 2025 projects.

George Clooney (Dr. Doug Ross)

George Clooney’s career is the most famous post-ER success story, transitioning from a television heartthrob to an Oscar-winning actor, director, and producer. His recent activity shows no sign of slowing down. In 2024, Clooney starred alongside Brad Pitt in the action-comedy film Wolfs, a major cinematic event that reunites the two Hollywood titans.

Looking ahead, Clooney has also confirmed that a fourth film in the highly successful Ocean's franchise is moving forward, indicating a return to one of his most beloved roles. His continued work as a director and activist ensures he remains one of the most powerful figures in the industry.

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Noah Wyle (Dr. John Carter)

For fans who missed Dr. John Carter's bedside manner, Noah Wyle is making a highly anticipated return to the medical drama genre. Wyle is starring in the new Max series, The Pitt, which is scheduled to premiere in January 2025.

The series, which sees Wyle playing a doctor once again, has already generated significant buzz. Beyond acting, Wyle is also flexing his directorial muscles, having directed an episode of the new HBO Max drama, a role he also took on during his time on shows like Falling Skies.

Maura Tierney (Dr. Abby Lockhart)

Maura Tierney, who played the fan-favorite Dr. Abby Lockhart, has had an incredibly busy 2024. She joined the cast of the long-running procedural drama Law & Order for its 24th season, taking on the role of a Lieutenant. This move places her back on a major network show, proving her enduring appeal.

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In addition to her new series regular role, Tierney appeared in the Prime Video series American Rust: Broken Justice and the natural-disaster thriller film Twisters in 2024. Her diverse range of projects highlights her versatility across different genres.

Eriq La Salle (Dr. Peter Benton)

Eriq La Salle has successfully pivoted his career to include significant roles behind the camera as a director and producer. However, he also returned to acting in 2024/2025 with the Prime Video police drama On Call.

La Salle took on a trifecta of roles for the project, serving as a star, director, and executive producer. This high-profile Dick Wolf-produced streaming series demonstrates La Salle's commitment to both performing and shaping stories from a directorial standpoint.

Julianna Margulies (Nurse Carol Hathaway)

Julianna Margulies, a multi-Emmy and Golden Globe winner, continues to choose high-quality, prestige television projects. Following her acclaimed run on The Good Wife, she joined the star-studded cast of the Apple TV+ series The Morning Show for its second season.

Beyond acting, Margulies released her memoir, Sunshine Girl: An Unexpected Life, offering a personal look into her life and career, including her time on ER. Her focus remains on powerful, character-driven roles and literary endeavors.

Anthony Edwards (Dr. Mark Greene)

Anthony Edwards, beloved for his portrayal of Dr. Mark Greene, has focused on a mix of film, television, and stage work. While his post-ER career includes roles in shows like Designated Survivor and films like Top Gun (pre-ER), his most recent high-profile appearance was the highly anticipated Broadway play Prayer for the French Republic.

Edwards remains an active and respected figure in the industry, often lending his talents to directing and producing, in addition to his acting roles.

The 2024 Reunion and ER's Enduring Legacy

The most exciting news for fans in recent memory was the surprise 2024 reunion of four of the show’s original stars. George Clooney, Julianna Margulies, Noah Wyle, and Anthony Edwards came together in New York City to celebrate the opening night of Clooney’s Broadway show.

The photo, shared by Wyle, instantly went viral, offering a heartwarming glimpse of the "County General" crew together again. This moment underscored the deep, lasting friendships forged on the set and the show's incredible cultural impact that still resonates today.

ER, which premiered in 1994, redefined the medical drama genre with its fast-paced, realistic portrayal of emergency medicine. It was a critical and commercial phenomenon, influencing countless shows that followed. The cast’s ongoing success in 2025, with major roles in new series like The Pitt and blockbusters like Wolfs, ensures the legacy of the show is not just a memory, but a continuous part of the entertainment landscape.

The enduring appeal of characters like Dr. Doug Ross, Nurse Carol Hathaway, and Dr. Mark Greene is a testament to the show's brilliant writing and the powerful performances of its ensemble cast. Whether they are back in scrubs or starring in a new action film, the ER alumni continue to captivate audiences worldwide.